Efficacy of topical cyclosporine 0.05% eye drops in the treatment of dry eyes
Haitham Y. Al-Nashar
J Egypt Ophthalmol Soc 108:233?236
Purpose: The aim of the present study was to detect the effectiveness of cyclosporine 0.05% eyedrops for treatment of patients with dry-eye disease.
Patients and methods: A total of 35 eyes of 20 dry-eye patients were included in the present study. Ten patients (20 eyes) had dry eyes associated with systemic rheumatologic disease (Sj?gren?s syndrome), five patients (10 eyes) had dry eyes after undergoing laser in-situ keratomileusis, and five patients (five eyes) had dry eyes after cataract surgery. Detailed history taking with complete ophthalmic examination was carried out for all patients. Break-up time (BUT) test and Schirmer?s test were done for all patients. The patients were examined for ocular symptoms of dry eyes (eye pain, eye burning, and sensation of
…show more content…
Patients and methods
In this study, 35 eyes of 20 patients with dry-eye disease were included. Ten patients (20 eyes) had dry eyes associated with systemic rheumatologic disease (Sjogren?s syndrome), five patients (10 eyes) had dry eyes after undergoing laser in-situ keratomileusis (LASIK), and five patients (five eyes) had dry eyes after cataract surgery. The patients were treated with cyclosporine 0.05% eye drops.
Detailed history was taken from all patients, including age, sex, previous medical and ocular diseases, and duration of symptoms. For all patients, routine ophthalmic examination was carried out. Slit-lamp biomicroscopy, break-up time (BUT) test and Schirmer?s test were also conducted. Before the beginning of the treatment the patients were examined for ocular symptoms of dry eye (ocular pain, burning, and foreign body sensation). Each symptom was given a score from 0 to 1 so that the ocular symptoms were given a score from 0 to
People affecting with rosacea (facial redness and swollen bumps under the skin) are at more risk to have certain eye problems like blepharitis and chalazia. In this condition, the narrow opening through which a meibomian gland secretes its material becomes clogged from narrowing of the opening or hardening of the sebaceous liquid near
Following successful studies using TB-500 by researchers at Wayne State University School of Medicine to together with the Kresge Eye Institute in Detroit, Michigan, RegeneRx Biopharmaceuticals, Inc published the results of this study which showed that thymosin beta 4 was an active corneal wound healing and anti-inflammatory agent Thymosin beta 4 is a protein that naturally occurs in all cells except in erythrocytes. Despite this protein being a key monomeric actin-sequestering peptide within cells and with ability to depolymerize F-actin, studies are showing that it has several diverse cellular functions. In this particular study, the researchers investigated the multiple mechanisms of action associated with Thymosin beta 4 and the role it
At the beginning of this case study, a woman in her forties presented with symptoms of dry eye alongside numerous dysfunctions in her right side facial movement and sensation. The dry eye symptoms were causing her discomfort and the facial dysfunction consisted of an extended time between blinks, incomplete right eye closure, forehead smoothing and drooping of her mouth. When evaluating this patient’s symptoms, it seems that the problems relating to dry eye are very likely secondary to the facial dysfunction that is visibly apparent. Specifically the fact that the patient has reduced blinking activity and is suffering from lagophthalmos, incomplete eyelid closure, would lead to a deterioration and lack of replenishment of the tear film layer
You must not be suffering from any auto-immune diseases and there should be no corneal
Unexpectedly, this syndrome is an inflammatory disease of glands and other tissue of the body. Inflammation of the glands that produce tears to decrease tears and dry eyes. It’s also, Inflammation
The plan of management was to admit the patient with the following treatment: preservative-free artificial tear drops every 1 hour, erythromycin eye ointment every 2 hours, moxifloxacin eye drops every four hours, Tobradex eye drop ( tobramycin + dexamethasone 0.1%) every 6 hours & cyclopentolate eye drops every 8
Elaine Yanyi Cen COM1010- Informative Speech outline EMEB, MW 2:30 PM -3:45 PM Dry eye or Tear dysfunction syndrome Introduction I. Many times patients may have itchy eyelids from a dry eye condition. So what do they do? They think they must have allergy condition. They go to local pharmacy and they grab over the counter, a tear drop that treats allergy.
Tear Film Tear film abnormalities are frequent in persons with diabetes, leading to an increased incidence of dry eye. The presence of an abnormal tear film may contribute to discomfort and to an increased risk of ocular surface epithelial defects. Longstanding diabetes may also damage the mircrovascular supply to the lacrimal gland, impairing lacrimation. Cornea Corneal wound healing The cornea of a person with diabetes is more susceptible to injury and slow healing after injury than the cornea of a person without diabetes.
Three Treatments for Dry Eyes Now, the first thing that pops into most consumers' head is the over-the-counter eye drops they can pick up at the local pharmacy. Those are okay for the occasional dry eye moment. However, they are not formulated for long-term use and they don't treat the underlying problem.
INTRODUCTION Phacomorphic glaucoma is defined as secondary angle-closure glaucoma due to an increase in lens thickness and is characterized by a sudden rise in IOP which can compromise the function of the optic nerve and may lead to irreversible visual loss if not treated in time. This increase in lens thickness can be due to an advanced cataract, a rapidly intumescent lens, or a traumatic cataract, eventually leading to pupillary block and angle closure. Phacomorphic glaucoma is peculiar to developing countries like India, (constitutes 3.91% of all cataract operations done) where the incidence of cataract far exceeds the total number of surgeries.1-5 Phacomorphic glaucoma is recognized by the complaints of pain and redness in an eye which
Group 1: Twenty five eyes for which a deep anterior lamellar keratoplasty was done using double bubble modification of the big bubble technique as described by Foroutan and Dastjerdi (2007). All cases were operated by a single experienced anterior segment surgeon. The recipient operative procedure was done first before stripping the descement membrane from the donor so as not to lose the graft if large DM perforation occurred and the surgeon decided to covert to PKP and it was done as follows: 1- Moxifloxacin HCl ophthalmic solution 0.5% was administrated for one to two days preoperatively, four times daily, to reduce the risk of infection.
However, when such complications occur, the cardinal question is when surgical intervention is indicated. Most authors recommend close clinical monitoring of such orbital signs as proptosis, gaze restriction and visual acuity as the best criteria for deciding upon surgical treatment.1,3,6,12,18,19-20 Antibiotic therapy was successful in 7 of 12 children (58%) in our series. This experience is comparable to that of Soulière et al. ,21 who reported a success rate of 50% with various combinations of intravenous antibiotic therapy which included chloramphenicol
It is important to educate the patient to avoid blowing their nose, as air from the Sino nasal tract can be forced into the orbit. This can result in an orbital compartment syndrome which can cause blindness. Periorbital edema can be decreased by putting cold compresses and by keeping the head of the patient on the bed elevated. Ensure that the eyelids can close in order to protect the ocular surface and more specifically the cornea, from exposure ophthalmic ointment can be
In the tear film, there is water, proteins, lipids, sodium, calcium, bicarbonate, and enzymes [The eye in contact lens wear- google]. If the contact lens is made up of a hydrophobic material, it will repel water which makes up the majority of the tear film. That will disrupt the tear flow, resulting in the deposition of an albumin film on the lens, which then reduces the effectiveness of contact. That can then cause infections and/or irritations [Contact lens polymer, accessed 31/03], [RCCL – review of cornea and contact lenses- contact lens complications- special issue], [Hydrogel contact lens surface roughness and bacterial adhesion – chapter
(2) Orbscan: (A) Screening for subclinical keratoconus: The data depicted and displayed by the Orbscan system have added a very important value to the diagnostic tools that may detect early keratoconus. The early diagnosis of subtle changes is critical for the evaluation candidates for laser vision correction, as well as providing early diagnosis and sensitive follow up of progression in the era of procedures designated to stabilize the corneal shape such as cross-linking. Being the first widely spread “catch-all” corneal topographer that provides posterior corneal surface mapping, Orbscan introduced a new era in refractive surgery and keratoconus diagnosis.