8. RESULTS AND DISCUSSION 8.1 PREFORMULATION STUDIES 8.1.1 Characterization of Oxubutynin chloride 8.1.1.1 Organoleptic properties The sample of OXB was found to be a white crystalline practically odourless powder. 8.1.1.2 Melting point Melting point of OXB was found to be in the range 124-129°C which is in range with the reported value (129°C). 8.1.1.3 Fourier transform infrared spectroscopic (FTIR) studies The FTIR spectrum of OXB is shown in Figure 21 and interpretation of FTIR spectra is given in Table 21. Figure 21: FTIR spectrum of pure OXB Table 21: Interpretation of FTIR spectrum of pure OXB Characteristic Peak (cm-1) Frequency (cm-1) OH stretching 3500.92 OH Bending 1084.03 C-H stretching 3095.95 C-N stretching 1105.95 C=O …show more content…
Table 24: Micromeritic characterization of OXB Sr. No. Parameters Result 1 Loose bulk density 0.28±0.03g/cm3 2 Tapped density 0.46±0.06g/cm3 3 Carr’s Index 37.44±0.03 % 4 Hausner’s ratio 1.59 5 Angle of Repose 26º 34’ From the above results it is evident that OXB exhibits poor flow properties. 8.1.2 Determination of solubility The solubility data for OXB as observed in 0.1 N HCl, pH 4.5 Acetate buffer, pH 6.8 Phosphate buffer and Purified water is presented in Table 25. OXB exhibited a pH independent solubility phenomenon in all pH conditions and various aqueous buffers. Table 25: Solubility data of OXB BCS solubility (pH solubility) profile of OXB Sr. No Media mg / ml 1 0.1 N HCl 249.119 2 pH 4.5 Acetate buffer 258.623 3 pH 6.8 Phosphate buffer 260.877 4 Purified water 253.200 *Average of three determinants 8.1.3 UV-VIS spectrophotometric method for OXB 8.1.3.1 Selection of …show more content…
MCC 101 Diluent 5. Mannitol Filler 6. Purified water Solvent 7. Aerosil Lubricant 8. Talc Glidant 9. Magnesium stearate Lubricant 8.3 Preparation of matrix tablets Seventeen different tablet formulations were prepared by using various polymers. First three formulations (F1A, F1B, F1C) were prepared by Wet granulation, Roll compaction and Direct compression methods respectively. The formula was same for all three batches. Among these methods direct compression method was selected for further trials as it was a smooth process compared to Wet granulation and Roll compaction and as well as it was observed that: Granules obtained from wet granulation were very hard and caused weight variation of compressed tablets due to varying size of granules during compression. Roll compacted blend showed problem during milling process and also showed flow variation due to rat holling in the hopper during compression. 8.4 Evaluation of powder blend Blends were prepared by mixing all the excipients. The blends were evaluated for different parameters and it was observed that moisture content was NMT 3% for each blend, Carr's Index (%) was in the range of 13.44±0.02 to 16.20±0.03, Hausner's
To prepare the solutions a 70% ethanol solution was used to make 40%. This was calculated using the C1V1=C2V2 formula. A photo spectrometer was used to measure, in arbitrary units, the change in membrane permeability of the B. Vulgaris cells. To begin, the B. Vulgaris samples were put into vials containing the distilled water, 40% and 70% Ethanol solutions. As soon as the B. Vulgaris samples were added to the vials a time zero sample was taken from the vials.
The following lab period the solid was weighed (0.0483 g) and percent yield was calculated (65.5%) with the limiting reagent being tetraphenylcyclopentadienone. The melting point was determined. The first melting point was 204-204.9 °C and the second melting point was 215.6-215.9°C. Finally, an infrared spectroscopy was obtained for the
Although this application has been discontinued, Chloroform is greatest known for it’s first use as an anesthetic. Prior to Chloroform, ether was the prevailing anesthetic for surgical procedures. However once Chloroform was introduced, ether was quickly replaced. Unlike ether, chloroform’s characteristically sweet odour isn 't irritating and was highly adored because it is 40 times sweeter than sugar. The sweetness of Chloroform coupled with it’s anesthetic properties made it a popular ingredient for toothpaste, cough syrup and skin ointments.
In particular, the formulation of rosuvastatin, molecule which is generally lipophilic, poses real problems owing mainly to their low solubility in aqueous liquid pharmaceutical excipients, to their propensity to precipitate or recrystallize in aqueous solution and to their low solubility in the fluids of the gastrointestinal tract from which they must be absorbed. The bioavailability of an active ingredient also depends on its concentration in the gastrointestinal fluid, said concentration itself being dependent on the release of the active ingredient. In particular, the more lipophilic an active ingredient is, the less tendency it has to migrate in gastrointestinal fluids.
introduction According to the oxford dictionary the definition of Slime mold is a simple organism of an acellular mass of creeping jelly like protoplasm containing nuclei or mass of amoeboid cells. When it reaches a certain size it forms a large number of spore cases and was formally considered in the kingdom of fungi, however it is now classified in the Protista kingdom because, like other protists, they really don 't fit in with other kingdoms. They are motile like animals but some are unicellular so they cannot be classified as animals. There are several types of Slime Molds. Plasmodial slime molds (such as Physarum polycephalum) are slime molds that form giant, multinucleated cell colonies.
Group 2: Anti - Inflammatory Bath Bombs Research Question : Is it possible to make anti -inflammatory bath bombs that are actually good for the skin ? Summary - Today bath bombs are all the rage or their cool explosions in baths and everybody just finds it fun and relaxing . However, according to draxe.com , “hormone-disrupting chemicals to possible disease-triggering dyes infiltrating your mucous membranes,” are inside bath bombs and so are , “synthetic scents are one of the most toxic ingredients in bath products” which can be harmful to the skin episodically people with bad skin conditions . For example, most of the food coloring used in most bath bombs can be toxic for your skin and also genital health
Nevertheless, the latter is not used in this experiment since it is very reactive and extremely flammable. On the contrary, NaBH4 is relatively mild and it can be used with protic solvents. In this manner, 1.507 grs of the ketone 9-fluorenone were mixed with 30.0 ml of 95% ethanol in a 125 ml Erlenmeyer flask. The bright yellow mixture was stirred during 7 minutes until all the components were dissolved.
Over the years glitter has become a worldwide phenomenon. From the gay underground scene of New York City to the catwalks of London Fashion Week, it’s uses, colour and shape have varied throughout the years. Glitter which is translated to ‘glitra’ meaning literally ‘to shine’ can be traced back to our ancestors. They would use innovative substances such as insects, stones or glass but today glitter is mainly produced from plastic and comes in a range of shapes and sizes making it all the more difficult to decide amongst them.
TLC was used to identify the actual unknown product as well as other products/reactants present in the filtered solution. The procedure was conducted by placing a TLC plate in a developing chamber that is filled with a small amount of solvent. The solvent cannot be too polar because it will cause spotted compounds on the TLC plate to rise up too fast, while a very non-polar solvent will not allow the spots to move. The polarity of the spots also determines how far it moves on the plate; non-polar spots are higher than polar ones. After spots on the TLC form, the Rf values are calculated and used to analyze the similarity of the compounds.
This ethics in practice case is about a beef company that started in the 1990s by Eldon Roth. This particular company used scraps from left over beef products to create a pink slime. This pink slime was treated, of course, to eliminate any harmful bacteria and advertised as a healthy beef additive. Pink slime was used at places like McDonald’s, Burger King, and Taco Bell. This company became extremely successful and before long they opened a plants in multiple locations and hired many employees.
This was proved by utilizing the IR spectrum to verify the C =O was not in the final product as it lacked the 1640 cm-1 peak. The melting point of 113-115 degrees C proved that the final product obtained was the E-Stilbene. The TLC plate proved that the E and the Z product was produced, show cased by the double intensity of the DCM spot to the final product’s spot, both which had an Rf of 0.92. The double intensity proved that both products were produced, but through heating and filtering, the Z-Stilbene was
The reagents used were Diphenylamine reagent which contains concentrated H2SO4. The standard solution used for this test is the deoxyribose standard solution. In the sample, only a faint blue solution appeared, which indicates a small presence of deoxyribose. In test for Phosphate, the standard solution was the Phosphate solution and the reagents used were concentrated H2SO4, concentrated HNO3, 2.5% ammonium molybdate solution.
Objective: Amongst the various routes of drug delivery for curing the buccal disease, mucoadhesive disc is one of them. The aim of this work was to design a mucoadhesive disc and formulation studies. Material&Methods: Discs containing 10% stem bark extract of ziziphus jujuba were formulated by Zinc Oxide, Glycerin, Carbopol 34, PVP K30 and Gelatin as excipients. These materials were mixed and changed to granules and then discs through direct compression. Properties such as in vitro and in vivo mucoadhesion, drug release, water uptake, disintegration were carried out.
Practical I: Acid-base equilibrium & pH of solutions Aims/Objectives: 1. To determine the pH range where the indicator changes colour. 2. To identify the suitable indicators for different titrations. 3.
Passing gas, especially very smelly gas, can be an embarrassing problem. Fortunately for anyone who experiences smelly gas, there are steps that can be taken to reduce the problem. In most cases, it is natural and healthy for a person to experience intestinal gas. An average person will pass gas multiple times per day.