4 Oxadiazole Research Paper

1,3,4-Oxadiazole (1) is a heterocyclic compound containing an oxygen atom and two nitrogen atoms in a five-membered ring. It is derived from furan by substitution of two methylene groups (=CH) with two pyridine type nitrogens (-N=) [1,2]. There are three known isomers: 1,2,4-oxadiazole (2), 1,2,3-oxadiazole (3) and 1,2,5-oxadiazole (4). However, 1,3,4-oxadiazole and 1,2,4-oxadiazole are better known, and more widely studied by researchers because of their many important chemical and biological properties.
Among heterocyclic compounds, 1,3,4-oxadiazole has become an important construction motif for the development of new drugs. Compounds containing 1,3,4-oxadiazole cores have a broad biological activity spectrum including antibacterial, antifungal, analgesic, anti-inflammatory, antiviral, anticancer, antihypertensive, anticonvulsant, and

1,3,4-Oxadiazole moieties are important because of their versatile biological actions.During the last decades, chemistry, synthesis and transformations of five membered heterocyclic compounds has received considerable attention and importance due to their remarkable and wide variety of applications. 2,5-Disubstituted-1,3,4-oxadiazole and its derivatives constitute an important family of heterocyclic compounds. Due to their remarkable unique properties, 1,3,4-oxadiazole and its derivatives have been frequently employed in drug synthesis, various commercial and industrial applications. In fact, 1,3,4-oxadiazole ring carrying substitution in an appropriate position and substituent with a nucleophilic center are excellent precursors for further synthesis of heterocyclic compounds. For example, ring rearrangements for the synthesis of five and six membered heterocycles. 5-Substituted-2-mercapto-1,3,4-oxadiazoles are interesting and important class of compounds. They have general formula (1) (R = alkyl or aryl