What is ambition? Ambition is the determination to achieve one’s goals. In the play Macbeth by William Shakespeare the protagonist, Macbeth, possesses ambition, which led to his downfall. In the play Macbeth’s ambition is driven by prophecies from witches and his wife’s aspiration. Ambition caused Macbeth to commit multiple homicides and after those wrongdoings Macbeth is left with nothing. At the end of the play, Macbeth’s ambition caused him to lose Lady Macbeth to suicide and to no longer have moral sense. Ambition led to Macbeth’s downfall because Lady Macbeth and the witches caused him to make brainless decisions that caused his collapse. Macbeth’s ambition led to his downfall because of Lady Macbeth's ambition. Lady Macbeth had