Azirines Derivatives Research Paper

Azrines derivatives have been reported to possess variety of activities against microbial organisms.
Azrines derivatives also showed other anticipated biological activities. Azrines also used in synthesis of various intermediates compounds for industrial purposes. These compounds have different functionalities in their structures. Azrines are widely used as antibacterial and cytotoxic. Some azrines azrines compounds have various functional groups.1-13
Azirine compounds and their biological activities:
Azirines are three membered heterocyclic unsaturated compounds containing a nitrogen atom and related to the saturated analogue aziridine. They are highly reactive yet have reported in a few natural products such as Dysidazirine. There are two

The photolysis of the azirine with the shortwavelength light (>300 nm) caused the C-C bond cleavage of the 2H-azirine ring to produce the nitrile ylide.31 The C,C-dicyanoketenimines were generated by flash vacuum thermolysis of ketene N,S-acetals or by thermal or photochemical decomposition of alpha-azido-beta-cyanocinnamonitrile. In the latter reaction, 3,3-dicyano-2-phenyl-1-azirine 12 is also formed. Nucleophilic substitution reactions of 2-halo-
2H-azirines with potassium phthalimide and aniline allowed the preparation of substituted 2H-azirines.
The reactions of 2-bromo-2H-azirine with methylamine led to the synthesis of alpha-diimines. 2-Halo-
2H-azirines were also established as building blocks for the synthesis of a range of heterocyclic compounds, namely, quinoxalines 10a-10d, 3-oxazoline, and 2H-[1,4]oxazines.32 Chemical reactions are described for the formation of aziridine-2-one and di-azirine-3-one derivatives as potential precursors for the original synthesis of amino-acids, proteins, pyrimidines, purines, nicotinamide and flavin.33

Though some of the compounds possess only modest biological activity, we hope to find a potent simple structural agent which can mimic the activity of the complex azirine through structural modifications of compounds. The literature reveals that azirine has biological potential, and the easy synthetic routes for synthesis have taken attention of the chemists, pharmacologists and researchers. The new class of substituted azirine has shown biological activities. The biological profile of these new generations of azirines presents much progress with regards to the old compounds. By the present scenario it can be concluded that azirine have potential which remain to be disclosed till date. Therefore, the synthesis of new compounds has become an important goal for researchers in recent years. For this purpose, various compounds incorporating a azirine ring have been synthesized and biological activities have been reported. Recently, it has been reported that a considerable number of azirine derivatives bear different biological activities. Among these compounds, azirine derivatives show various biological