Stages Of Angiogenesis

Angiogenesis something that if controlled can assist in research to help people with many diseases, from heart diseases, arterial diseases, and for anyone that obtains a wound. Angiogenesis itself is blood vessels that grow because of vasculature that already exists. It is something that every human being has, and it happens throughout life, weather a person is health or if they are sick. Angiogenesis is itself grows through about six stages, these stages are as followed: “Stage One: Endothelial cell activation by growth factors, Stage Two: Degradation of the capillary wall by extracellular proteinases, Stage Three: Formation of a branch point in the vessel wall, Stage Four: Migration of endothelial cells into the extracellular matrix towards

Folkman’s research we have to not necessarily go to the beginning of his life’s research, but right when he leaves the Navy, and not even necessarily with Dr. Folkman himself, but with Dr. Algire. With these men we start learning seeing how blood vessels work, firstly; with rabbits that when rabbits have had cancer inserted into their thyroids that this would trigger the growth of blood vessels, that cancer itself would be able to deceive the blood vessels to grow and feed the tumor making it about to expand and exploit the body’s natural ability to help heal itself. Later in an experiment, we can see this in a different way, with mice. With three different groups of mice, one group being the control just being injured through a surgical device and nothing assisting it, with inserting normal tissue into the second group, and inserting cancerous cells into the third group. Multiple days later the test results where in, and with the first two groups everyone was relatively fine. But, with the third group rather striking results were found, capillaries were expanding fast in the area, and within a few days the number of vessels had double around the surrounding tissues, and it the process seemed to not want to stop. This study kept going on and on, with findings always being that when there was a tumor around that blood vessels would always be prolific in trying to feed and assist the cancerous body. The next thing to do with this is to try to make it so you can isolate what is going on, and be able to study it by itself, but at first trying to grow endothelial cells in culture didn’t work, until it was decided that using fluid from a dogs thyroid glands, with early results being promising: platelets were doing more than just plugging leaks, but they were also assisting vessel staying alive for a longer period of time. But with dogs being too much of an expense in this type of work, rats were required for this type of work. But