The main purpose of the kidneys is to filter and reprocess blood. It 's an extremely complex process and cannot simply be likened to a sieve (“it is a device for separating wanted elements from unwanted material or for characterizing the particle size distribution of a sample, typically using a woven screen such as a mesh or net”). Wastes and extra water are removed to become urine, which flows from the kidneys to the bladder to be excreted whenever we feel the need to urinate. But the normal proteins and cells of the bloodstream that we need are returned back to the blood. In this way, the kidneys regulate the body 's levels of many substances, sometimes keeping them to a very narrow, normal range.
In Chronic Renal Failure, the renal system experiences ischemia, inflammation, necrosis, fibrosis,
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This classification includes treatment strategies for each progressive level, as follows:
• Stage 1 – This stage is characterized by kidney damage with a normal GFR (≥ 90 mL/min); the action plan consists of diagnosis and treatment, treatment of comorbid conditions, slowing of the progressing of kidney disease, and reduction of cardiovascular disease risks
• Stage 2 – This stage is characterized by kidney damage with a mild decrease in the GFR (60-90 mL/min); the action plan is estimation of the progression of kidney disease
• Stage 3 – This stage is characterized by a moderately decreased GFR (to 30-59 mL/min); the action plan consists of evaluation and treatment of