The Columbian Exchange was the movement of people, animals, goods, plants, diseases, and microorganism that occurred in the sixteenth century. The effects of The Columbian Exchange on early American society were extensive. One of the most devastating effects was the spreading of disease that killed around ninety percent of the Native American population. When Europeans came to the New World they brought with them diseases such as, “smallpox, measles, typhus, and cholera”(document one). The native’s immune systems were not prepared to fight theses diseases and this lead to a catastrophic amount of fatalities. In document four we see evidence of a smallpox breakout through an illustration of native americans with spots covering their bodies.