Columbian Exchange Start Point

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What would eventually become the start point of what is today called the Columbian Exchange started about 500 years ago when Christopher Columbus and his 3 ships set off to from Spain to find India. Instead of India, they discovered the New World, America. The exchange of animals and plants that took place after this would come to be very important to Europe and America.
After Columbus and his 3 ships arrived and reported back to queen Isabel another 17 ships were sent off to the New World, the word about the far away land spread along Europe and everybody wanted to take a part of this amazing land. After the British defeated the Spaniards the Settlers arrived to America and now is when the real exchange of plants and animals would take place.