The Columbian Exchange was a major turning point in U.S history. Once Columbus arrived in America there were a lot of drastic changes. For example, plant and animal species decreased. Many people died because of diseases and a lot more. The point of this paragraph is to see the major effects the Columbian Exchange had on Europeans and Native Populations, and that disease played a huge part in it. When the Europeans arrived in the country more than 50% of the Native Americans died. Most of the deaths were caused by smallpox and starvation. When they died from smallpox it decreased the number of people growing crops which then led on to starvation. The deaths of the Aztec and Incan broke out war, which causes the disease to spread even more.