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Emtricitabine Case Study

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Structure of Emtricitabine

b) Chemical Name / IUPAC Name: 4-amino-5-fluoro-1-[(2R,5S)-2-(hydroxymethyl)-1,3-oxathiolan-5-yl]-1,2-dihydropyrimidin-2-one

c) Molecular Formula: C8H10FN3O3S

d) Molecular Weight: 247.248 g/mol

e) Description: white to off-white crystalline solid

f) Melting point: 136 °C to140 °C

g) Solubility: Freely soluble in methanol and in water; practically insoluble in methylene chloride.

h) pKa value: 2.65

i) Route of administration: Oral

j) Excretion: Renal (86%) and fecal (14%)

k) Metabolism: Hepatic oxidation and glucuronidation CYP system not involved

l) Storage: Store at 25 °C (77 °F); excursions permitted to 15 °C-30 °C (59 °F-86 °F)

m) Trade name: Emtriva, Truvada (a fixed-dose combination with Tenofovir), Atripla (A fixed-dose triple combination of Emtricitabine, Tenofovir and Efavirenz)

2.2.4 Drug profile of Tenofovir: …show more content…

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