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High Cholesterol Familial Homozygous Case Study

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Treatment for: High Cholesterol, Familial Heterozygous, High Cholesterol, Familial Homozygous, High Cholesterol Definition: Repatha is a monoclonal antibody to a Proprotein Convertase Subtilisin/kexin type 9 (PCSK9) inhibitors they work similarly to statins and the genetic and it has negative regulator of low density lipoprotein receptor (LDLR). Repatha is a medicine used to treat adults with primary hypercholesterolaemia with high blood cholesterol levels. Primary means that the disease is generally the result of a genetic abnormality and hypercholestrolaemia includes heterozygous and when the genetic abnormality is inherited from only one parent. And it also used to treat mixed dislipidaemia and which abnormal levels of fats in blood including high levels of LDL cholesterol. …show more content…

Dose required for the repatha Warnings Hypersensitivity reactions (eg, rash, urticaria) reported, including some that led to discontinuation of therapy How people supposed to take it Use it as the healthcare provider tells you to use it Repatha is given as an injection under the skin every two weeks or a month for one time If your healthcare provider gives you a monthly dose u will be given three separate injections in a row Do not inject the repatha in the site of the other medicine injection Do not stop using the repatha without telling your healthcare provider if you will stop your cholesterol levels can increase How much the repatha will cost you Repatha will cost per patient about $14,100 for a year's worth of treatment FDA approved: Yes (First approved August 27th, 2015) Company: Amgen

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The Orphan Drug Act of 1983 was signed for the main purpose of promoting the research, treatment, prevention and diagnosis of rare disease or condition. Here the products which are used in rare disease can be drugs, biologics and medical devices. A rare disease means any disease which affects less than 200,000 persons in the United States or one in which the manufacturer has no expectation of recovering the money from development and sales in the United States. According to this act, there are certain incentives will be provided to the manufacturers who will develop orphan drug for the rare disease and condition. Thus, this act can encourage the treatment for rare disease.

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According to Dr. Thomas Lee of Harvard Medical School (1), the ingredients are chiefly an amalgamation of stanols and sterols, and include campesterol, beta-sitosterol and stigmasterol. Studies have shown that a combination of plant based stanols and stenols helps lower bad cholesterol (LDL) in the body by preventing the absorption of LDL in food. The active ingredients work by drawing LDL from the bloodstream, then converts the cholesterol into hormones and bile acid. Plant stenols and stanols look similar to Cholesterol and are very effective in blocking the uptake of cholesterol into the body. Research has shown that taking 2g of stanols or sterols from plant sources can reduce the LDL by as much as

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The cost of this treatment varies greatly by the filler selected, and patients can expect to pay anywhere from $467 to $1,682, on average. The face must always be assessed and mapped to determine where to place the fillers. The area then needs to be cleaned and anesthetized before the injection takes place. Finally, the treatment location has to be cleaned and the recovery process begins.

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The main medicine for reducing bad cholesterol is statins, but some patients cannot tolerate it or do not get enough help from the drug. The study involved both Praulent and a similar medication, Repatha, manufactured by Amgen. But Repatha works in a different way and lowers cholesterol much more. The study on Praulent took a longer time and involved patients at a higher risk of heart events.

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Reighn made friends at school and in the community. The peer interactions are positive and provide peer support. The youth is mostly talkative and reserved. Reighn displays positive aggression during passionate discussion.

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In the previous five decades, the movement of prescription has been fast and dynamic. Therapeutic examination has set down into investigation and discovering cures for some illnesses through surgical strategies, medications and antibodies thus over the long haul enhancing the wellbeing models and life range of people as a rule. This is in course to a customized prescription, "the fitting of medicinal treatment to the individual attributes of every patient. It doesn't truly mean the formation of medications or restorative gadgets that are interesting to a patient, but instead the capacity to order people into subpopulations that vary in their helplessness to a specific sickness or their reaction to a particular treatment". Because of variety in the human genome, medicinal treatment including medications and treatments may be for a particular gathering of individuals.

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Herbal products have been used for treatments since ancient times, before the exploration of synthetic industrial drugs. Since herbs are natural, most of the consumers believes herbal products are completely safe and the product use continuously increased and is reported 10-19% growth in United States. In U.S.A any botanical product affects the structure and functions of the body belongs to either a drug or dietary supplement and FDA regulates the dietary supplement. The author of this paper selected St. John’s wort ,as the herbal supplement for this assignment of patient educational flyer. Product Description: St. John’s wort (SJW) is a yellow flowering plant, grows in the wild used for health purpose for long time .The

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There are people who had some success but it seems that those who do use the drug in conjunction with other things like a good diet, some exercise or they combine it with some other fat burning compound. One advantage that should be mentioned though is that Garcinia Cambogia encourages your body to use glucose instead of storing it in pockets of fat. This could have a greater impact for people with diabetes but studies on how it affects Glucose are still being conducted, on lab rats. In retrospect, Garcinia Cambogia should have some effect on cholesterol levels. Health Claims:

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A monthly dose comes out to about fifteen dollars, on the high side. Fifteen dollars a month is inexpensive peace of mind that your pet is going to be happy, healthy, and protected from fleas, ticks, and other nuisance pests. When you apply the medication to the back of your dog's neck it is quickly absorbed into the glands under the dogs' skin. It does not just sit on top of the skin. It is slowly released by the body over the period of about a month.

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Heredity is basically the passing on of genetic traits from parents to offspring. Both phenotypes and genotypes are passed down from one’s parents. A genotype is the genetic code of one’s cells. These genetic codes consist of paired alleles and often fall into three categories: homozygous dominant (BB), Homozygous recessive (bb), and Heterozygous (Bb). Phenotypes are the physical expression of genotypes, for example, whether someone has freckles vs. if someone does not have freckles.

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