In September 1928, from Alexander Fleming’s accidental discovery and isolation of penicillin marks the start of modern antibiotics. Before that, several scientists had published or pointed out that mould or penicillium sample were able to inhibit bacterial growth, and even to cure bacterial infections in animals. Alexander Fleming was the 1st who push past studies further by isolating the penicillin and by being motive enough to promote his discovery at a larger scale. He also discovered that bacteria developed antibiotic resistance whenever too little penicillin was used or when it was used for too short a period. Alexander Fleming cautioned about the use of penicillin in his many speeches around the world that not to use penicillin unless