C4564 Description: IC50: 3-AP is a ribonucleotide reductase inhibitor and iron chelator with antitumor activity. Ribonucleotide reductase, the rate-limiting enzyme for de novo DNA synthesis, is an excellent target for chemotherapy. Its increased activity in cancer cells is associated with malignant transformation and proliferation.
The study also found that an increase in γ-H2AX (a marker for DNA double-strand breaks) and a decrease in RAD1 (a marker of HR directed DNA repair) focus-positive cells was associated with a depletion of MEN1 expression as predicted. The study also predicted that NHEJ could function to repair double strand breaks, and would increase with a loss of MEN1 functionality. The study found this prediction to be true. The study also investigated the role of ATM and ATR DNA damage kinases in relation to MEN1, and found that MEN1 is protected from ubiquitin mediated degradation through phosphorylation by ATM and ATR protein kinases. One of the most significant results from this study involved determining the functional relationship between the expression of HR target genes and MEN1, as well as investigating the mechanism of action involved in the cellular process.
There is still more research that needs to be down with this protein to determine more about genetic diseases and
The theme of loss in literature, is an incident that most characters have to face within their story. How characters deal and overcome with losing something, can make them weaker or stronger. In the two literary works, a wife and husband lose important elements in their marriage, needed to sustain their boned relationship. In the short story “Answers,” in “Half-Mammals of Dixie” by George Singleton and the poem “Conjoined,” by Judith Minty, a wife and husband lose trust, connection, and unity within their marriage, revealing that the breakdown of trust results in devastating loss.
Below the turquoise waters of Mexico’s Yucatán Peninsula lies the site of a long ago mass murder. In a geologic instant, most of the world’s animal and plant species went extinct. Drilling through hundreds of meters of rock, investigators have finally reached the "footprint" left by the accused. That footprint marks Earth’s most notorious space rock impact. Known as Chicxulub (CHEEK-shuh-loob), it’s the dinosaur
Lennie’s Animalistic Insight Mice, bears, horses, rabbits, and puppies are all animals that are compared to or connected to the character Lennie. Whom is a character from the novel Of Mice and Men by John Steinbeck. Throughout the novel readers follow two ranch laborers, Lennie and his minder George, strive for their dream; however, Lennie, being the complicated character with flaws he is, makes grievous mistakes. Additionally, all the animals, like a horse, pup, and bear, are compared and connected to Lennie by Steinbeck to give the reader an insight on his character.
Changing Our Outlook of Animals During the Period of 1800 to 1910 Short Essay Concerning the period of 1800 to 1910, many movements were formed addressing the lives and suffering of animals. Such movements granted better welfare for animals as well as a sentient outlook towards them. Animal protectionists in the nineteenth century worked to create legislation that granted animals immediate legal protections, as well as large-scale public education efforts to explain the harm of cruelty to animals in terms of the animals’ suffering[1]. As stated by Pearson in the Cow and the Plow, animal suffering was simply one of many potential definitions of cruelty’s damages, and when judges and other legal interpreters read animal protection statutes,
Climate change influenced nonhuman primate evolution by forcing the evolution of species and creating new environments that allowed for primates to live. "A rapid temperature increase around 55 mya ... led to an expansion of evergreen tropical forests, the environment that made possible many mammalian groups, including primates." (pg. 260). As rapid temperature increase created new environments a rapid cooling in the beginning of the Oligocene limited the range of habitats greatly. Due to this reduction a majority of the primates during this time lived around the fayum region in northeast Africa.
“Non-human primates, due to their level of intelligence when compared to other animals, and also due to their evolutionary closeness to man are maintained in several types of captive facilities like laboratories, zoological parks, animal circuses and conservation breeding centres” (Mallapur 2005). They are kept for observation and studies but many of these captive conditions evoke abnormal behavior patterns among non-human primates. Maintaining a satisfied non-human primate in captivity can be challenging. They are many important variables to take into consideration. When the enclosure does not suit the needs of a nonhuman primate it can affect their behavior physically and psychologically.
Studying captive primates can help us learn not only how they behave, but also how they are similar or different to each other and humans as well as give us insight into the effects of captivity. This paper will be describing, comparing, and contrasting the behavior of two species of captive primates at the Alexandria Zoo, golden lion tamarins and howler monkeys, as well as discussing the possible effects captivity could have had on them. This paper will also discuss any human-like behaviors observed in the two primate species and what we as humans could learn about our own behavior by studying primates. The two primates I observed were 1 of 3 golden lion tamarins (Leontopithecus rosalia) all of unknown gender and a solitary female howler
In section 3. Why Animalism is Unpopular, of “An Argument for Animalism,” Eric Olson argues that animalism is unpopular amongst contemporary philosophers. Animalism, according to Olson, is a theory that humans are numerically identical to animals (“An Argument for Animalism”, 610). This means that there is a particular human organism and that organism is you; the human organism and you are one in the same. When thinking about personal identity, Olson reasons that contemporary philosophers don’t ask what kind of things we are.
Social Media Essay Imagine if all the years of hard studying and late nights staying up, doing homework was taken away by one post on social media. Social media accounts can be used against a college student or it can be used as a tool for college students to help get accepted; it all depends on how one uses it. Colleges should be able to use social media because college is a privilege for people to attend and if people really want to go to college they should be able to clean up their accounts, a lot of people want to use social media as a helpful tool to get accepted, and because colleges have to be so selective in who they take into their school they should have the right to look at a student’s profile if it is public. One reason that colleges should be able to use social media is the fact that college is a privilege and students should be able to clean up their social media profiles if they really want to get accepted.
The mutation which causes the syndrome was found in the “RAS-Mitogen-Activated Protein Kinase (RAS-MAPK),” (Pierpont, Tworog-Dube, & Roberts,
In the sixth grade, I took a test to see if I was left- or right-brained. To my elementary eyes, the result of that quiz would be the truth from on high—a resolute word that would define the man to come as either analytic or artistic. Unfortunately, the oracle I sought gave me a perplexing answer. Much to my disbelief, my tallied score yielded a perfect split down the middle. Was I mentally ambidextrous or mentally challenged?
[Internet]. Cell Viability Assays. Bethesda (MD): Eli Lilly & Company and the National Center for Advancing Translational Sciences. [cited 2017 Feb 4]. Available from https://www.ncbi.nlm.nih.gov/books/NBK144065/ Stoddart, M. 2011.
