ipl-logo

Marilyn Carter Case Study

976 Words4 Pages

I am writing to attest to the work and merit of Dr. Marilyn Carter. Dr. Carter’s research in the field of Neuroscience continues to extend across diseases and from the intimate, scientific workings of the brain to the practical applications of findings. As Dr. Carter’s Ph. D. advisor, I have had the opportunity to see the processes and applications of the research that Dr. Carter has done and is continuing to do. Therefore, I wish to make a statement on her relevancy and importance. First, allow me to provide a summary of my own position in the field of Neuroscience. I am a Professor of Neurosciences and Neurology at Case Western Reserve University in the School of Medicine. I am also the Principal Investigator and Director at the Alzheimer …show more content…

Carter formed her hypothesis that manipulating ApoE in the brain can lead to Aβ clearance and may slow the progression of AD and possibly cure the disease. With the knowledge that nuclear receptors liver X receptor (LXR) and retinoid X receptor (RXR) regulate ApoE expression, Dr. Carter investigated Bexarotene, an RXR agonist. Her research showed that administering Bexarotene to AD mice improved previously impaired memory, cognitive functions, and social behaviors. By choosing to investigate a drug already approved by the FDA for treatment of lymphoma, Dr. Carter proved her efficiency in the field; approval for a new drug would have been much more difficult to obtain when she moved to clinical …show more content…

Carter’s unique research into AD by fighting not the genetic potential, which accounts for a small portion of patients, but by confronting the variances in ApoE, which account for over half of all AD cases, has provided a basis for developing effective treatment for AD. We published two papers on the topic, one in Neuron concerning the initial findings and one in Science about the pharmacological intervention. Dr. Carter’s work also was discussed in an article found in the Wall Street Journal entitled, “Attack on AD: Cancer Drugs Aid Symptoms.” The work that Dr. Carter has done and continues to do in the field of neurodegenerative diseases can benefit the quality of life for patients and families affected by AD, as well as potentially reduce the healthcare costs in treating those individuals, as discussed by the Wall Street Journal

Show More
Related
793 Words | 4 Pages

Introduction Alzheimer’s is a chronic neurodegenerative disease that usually starts slowly and gets worse over time. The most common early symptom is difficulty in remembering recent events or short memory loss. As the disease advances, symptoms can include difficulty with language, disorientation, mood swing and behavior problems. As a person 's condition progressed, they often withdraw from friends and family. Slowly, bodily functions deteriorated and eventually death occurs.

Read More
433 Words | 2 Pages

Villegas Although it was not that long ago that I started doing research, Dr. Villegas has given me the privilege of working in his lab. He is currently conducting research on a rat model of Alzheimer’s disease (AD). Working with Dr. Villegas has allowed me to learn new scientific methods and facts. Such methods and facts include, but are not limited to, tissue sectioning, electrode implantation, and recording data.

Read More
401 Words | 2 Pages

End They shape their argument in the end by saying how the government does not put nearly as much money as they do towards other diseases and that there is a possible cure in testing. “In March, biotechnology company Biogen unveiled an anti-amyloid called aducanumab, or "adu" — the first drug that has substantially reduced the brain plaque associated with Alzheimer 's in a human trial”. 4. The author uses a serious tone by giving facts that portray the need for a cure.

Read More
652 Words | 3 Pages

Alzheimer’s disease is a specific cognitive impairment that falls under the dementia umbrella. Currently there is no cure and researchers are still looking to find the cause for diseases like Alzheimer’s. It is important, as the baby-boomer generation ages, to make sure the general public is educated on common myths and misconceptions about dementia. 1.

Read More
1100 Words | 5 Pages

Our knowledge about how the human brain works is in debt to numerous unfortunate individuals. In the early 20th Century, they were considered medical miracles, but nevertheless some pitied them. By doing so, these people that were attempting to live normally were constantly reminded of their disability(ies) to a point of exhaustion. Henry Gustav Molaison, for example, is one of the most known patients in Neuroscience. Known by H.M. until his death, he was a “neuropsychological phenomenon” that helped discover significant advances in understanding the function of memory in the “hippocampus”.

Read More
719 Words | 3 Pages

Cancer Drug Offers New Hope for Parkinson’s and Alzheimer’s Diseases The movie “Awakenings” aside, there’s no really good treatment for the half a million Americans living with Parkinson’s disease. Dopamine-replacing drugs often help control the movement disorders that are the hallmark of the disease. But they don’t work for all patients, and they don’t bring any relief from the cognitive effects of the disease — in fact, they often make them worse. That’s why there’s a lot of excitement about a small study using nilotinib (Tasigna) to treat Parkinson’s disease. The drug, approved by the Food and Drug Administration (FDA) to treat cancer, suppresses tumor growth by spurring cells to do some housecleaning.

Read More
1191 Words | 5 Pages

Student Name: Kayla Stradomski Course # and Section/Time: COMM 101 DAH; Monday, 11:00 a.m. - 1:50 p.m. Topic: Alzheimer’s disease General Purpose: To inform Specific Purpose Statement: To educate my audience on the aspects of Alzheimer’s disease. INTRODUCTION Attention Getter: Can you imagine your life if your memories and cognition slowly started deteriorating?

Read More
870 Words | 4 Pages

Adrenoleukodystrophy is a type of genetic condition brought about by the lack of the functional organelle peroxisomes. ALD damages the membrane that wraps around the nerve cells in the brain. Adrenoleukodystrophy, or ALD, is a deadly disease that is estimated to affect 1 in 17,000 newborns, and starting in 2015, some states in the U.S. have added a simple blood test to detect ALD at birth. It affects boys and men. ALD is most apparent in children between the ages of four and ten.

Read More
200 Words | 1 Pages

The brain is complex, but vulnerable. Over sixty million US citizens have brain issues such as developmental diseases, which include: learning disorders, and autism spectrum disorders. Others include antisocial behaviour and schizophrenia that originates in childhood and continues throughout his or her life. Degenerative diseases of adult life include: Alzheimer’s disease, amyotrophic lateral sclerosis (ALS), Huntington’s disease, and Parkinson’s disease, among others. These diseases often affect elderly adults and are caused by the deterioration of nerve cells, eventually leading to the death of cells.

Read More
547 Words | 3 Pages

Lecture Extra Credit Due to my lab time I arrived at the lecture around 4:30. When I arrived she began to compare results of neuromuscular control before and after their intervention. The results lead them to the promotion of preventive trains programs.

Read More
149 Words | 1 Pages

The brain and how it works has been something very captivation for the human mind. Van Wedeen is a scientist that been analyzing how the brain works He has stored hundreds of brains of different kinds in 3-D images. His collection goes from monkeys, rats, and humans brain. This scientist is “ creating in unprecedented detail representations of the brain's wiring: the network of some 100,000 miles of nerve fibers, called white matter, that connects the various components of the mind. Through this kind of network neuroscientist can see the brain’s flaws, which give them the capacity to identify differences in the structure of ordinary brains and also, brains of people with some disorders such as schizophrenia, autism, and Alzheimer's disease.

Read More
1419 Words | 6 Pages

Mutually, contradictory results of neurological tests can not be regarded as allegedly scientific confirmation of existence and/or the lack of free will. Neither premise should not be underestimated, but even complexity and the mysteriousness of our brains gives rise to scepticism and uncertainty as it remains

Read More
240 Words | 1 Pages

Today, scientists build off of old and new brain research to try and figure out what areas of the brain they have not discovered. They work together to come up with new technology that will benefit the world. A couple discoveries that have been made are being able to read a mouse’s mind, and prosthetics that connect with the brain. To read the mind of a mouse, they show the mouse an image and then

Read More
456 Words | 2 Pages

In his book, author Oliver Sacks tells the accounts of many of the stories he has encountered throughout his career as a neurologist. Each individual story ranging from a variety of different neurological disorders, displays a common theme which add to Sacks’ overall message conveyed. The themes that are conveyed by Sacks include losses, excesses, transports, and the world of the simple. Each theme consists of grouped stories that coincide with the overlying message. In the losses section, the nine chapters all deal with some sort of deficit inside of the brain.

Read More
1391 Words | 6 Pages

Dementia is one of the most feared diseases and expensive to society currently. It is defined as a clinical syndrome of acquired cognitive impairment that determines decrease of intellectual enough capacity to interfere social and functional performance of the individual and their quality of life. It is a known fact that patients tend to express themselves through their behaviour and expect their carers to understand this notion. The diverse kinds of causes of different behaviours are inability to communicate, difficulty with tasks, unfamiliar surroundings, loud noises, frantic environment, and physical discomfort. Many diseases can cause dementia, some of which may be reversible.

Read More

More about Marilyn Carter Case Study

Related Topics

Open Document