Metronidazole Research Paper

A. INTRODUCTION
DESCRIPTION
 Metronidazole is 1-(2-hydroxyethyl)-2-methyl-5-nitroimidazole B.P. It appears as a white to
 brownish cream crystalline substance with melting point 159-162C. Solubility in water at 20C is
 1g/100mL; in ethyl alcohol, 0.5g/100mL; in chloroform, 0.4g/100mL; slightly soluble in ether and
 soluble in dilute acids. When reconstituted as Metronidazole IV for Infusion, it has a pH of between 4.8 and 5.2.
B. Composition
 Each ml contains metronidazole B.P. 5mg, anhydrous citric acid B.P. 0.4mg, sodium phosphate B.P.
 1.5mg and sodium chloride B.P. 7.4mg. Each ml contains 0.135mmol of sodium.
C. Classification and Activity
 Metronidazole is a nitroimidazole antiinfective agent which has specific activity against

The active agent is dispersed or dissolved in an inert polymer.
The term microcapsule is defined as a spherical particle with size varying from 50 nm to 2mm, containing a core substance. Microspheres in a strict sense, spherical empty particles. However, the terms microcapsules and microspheres are often used synonymously.
In addition, some related terms such as “microbeads” and “beads” are used alternatively. Microspheres can be defined as solid, homogeneous, monolithic, approximately spherical particles in the size range of about 0.1 – 1000 µm and are widely used as drug carriers for sustained or controlled release.
They are made of polymeric, waxy or other protective material that is biodegradable synthetic polymers and modified natural products such as starches, gums, proteins, fats and waxes, natural polymeric material such as albumin, gelatin; synthetic polymers. These “spheres” can then release the drug via the surface or bulk degradation

of the polymer, with release kinetics controlled by type of polymer used and its properties. Solvents used to dissolve polymeric materials are chosen according to the polymer and drug solubility and stability, process safety and economic