MEVACOR ( also called as LOVASTATIN ) :
Mevacor ( Lovastatin ) is a statin drug, used for lowering cholesterol in people who are suffering with hypercholesterolemia to reduce the risk of cardiovascular disease. Lovastatin is a naturally occurring compound found in low concentrations in food such as oyster mushrooms, red yeast rice and Pu-erh.
History
# : Compactin and Mevacor, natural products with a powerful inhibitory effect on HMG-CoA reductase, were discovered in the 1970s, and taken into clinical development as potential drugs for lowering LDL cholesterol.
# : In 1982, some small-scale clinical investigations of lovastatin, a polyketide-derived natural product isolated from “Aspergillus terreus”, in very high-risk patients were undertaken,
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# : Mevacor tablets are preserved by storing them in well-closed, light-resistant containers in a cool place or at controlled room temparature.
ZARAGOZIC ACIDS :
Zaragozic acids belongs to the family of natural products produced by fungi.
The first synthesised zaragozic acids A,B and C were isolated from an unidentified sterile fungal culture,"Sporormeilla intermedia".
This family of natural products possesses a unique 4,8-dioxabicyclo[3.2.1]octane core, and vary in their 1-alkyl and their 6-acyl side chains.
“ ZARAGOZIC ACID A ”