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Monoamine Oxidase Antidepressant

846 Words4 Pages

1.Introduction The incidentally discovery of monoamine oxidase inhibotor (MAOI) iproniazid and the tricyclic antidepressant (TCA) imipramine in the late 1950s were major breaktroughs in the treatment of depression. The discovery of imipramine initiated a search for new tricyclic antidepressants. Lundbeck (pharmaceutical company) developed new patentable syntheses three drugs as amitriptyline (1), nortriptyline (2), melitracen (3) and entered the market with these products at early 1960s. However, TCAs has several serious side effects, such as dryness of the mouth, constipation, confusion, dizziness, sedation, orthostatic hypotension and tachycardia. For that several serious side effects of TCAs chemists started to look for ways to improve TCAs. …show more content…

The basis was thus established for clinical studies in patients with a view to obtaining marketing authorisation. Normally, studies are carried out to show the relationship between effect/side effects and dosage. However, on the basis of data from earlier studies with citalopram, and the pharmacological studies with escitalopram, it was possible to predict which doses of escitalopram were likely to show a clinically relevant effect. It was therefore not necessary to conduct preliminary studies in patients (phase II), and Lundbeck could move on directly to large-scale studies in patients (phase …show more content…

In these studies, the effect of escitalopram was compared to that of an inactive control (placebo). The clinical studies were coducted on three continents and in 21 countries. Approximately 170 centres participated in the studies, and recruitment of the more than 2,000 patients was completed in record time. Since SSRIs are mainly perscribed in general practice, it was extremely important for the studies to be conducted in a primary care setting. The studies were therefore conducted in a specialist setting and in general

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Compound 17392

691 Words | 3 Pages

They were to report on patients’ side effects, patients use of the drug, and both patient and physician subjective evaluations. Physicians who were interested in participating in this research would be paid three hundred dollars for ever patient they entered into the study, as well as an additional three hundred for the patients who participated in a one year follow up evaluation. The payment in this case was considered compensation for physician’s time and effort.

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Pros And Cons Of Pseudobulbar

1412 Words | 6 Pages

The drug amitriptyline is antidepressant that helps with pain and the incontinence. It can be taken orally using around 25 to 150 mg dosages, the option of injection is also available for patients. One of the advantages of this drug is that it can help subdue the symptoms of PBA that resemble depression. This drug also has a few cons. It causes extreme swelling of the face, tongue, lips, and face.

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611 Words | 3 Pages

My preceptor and I discussed both the dangers of this class of medications as well as their usefulness. We also discussed the fact that there is new research to

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1703 Words | 7 Pages

I don’t understand why he would receive risperidone as medication if the very side effects are the very components he is struggling with. It comes off as counterproductive. Some how this medication is suppose to be the quick fix solution to his problems. It doesn’t seem as it benefited from taking the pills in the long run. The medical model looks at whats wrong with a person, but neglects the individual’s needs.

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3223 Words | 13 Pages

Introduction: Quetiapine Fumarate (QF) is a psychotropic agent indicated for the treatment of schizophrenia and manic episodes associated with bipolar disorder. QF possesses good solubility in aqueous fluids (1) and ethanol. Quetiapine is available in the market with the brand name of Seroquel XL (2). Inadvertent, rapid drug release in a small period of time of the entire amount or a significant fraction of the drug contained in a prolonged release dosage form is often referred to as “dose dumping”. Jhonson F. et al.

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Ap Psychology Quiz

1107 Words | 5 Pages

Serotonin syndrome can be caused by the use of: a. SSRI’s and Monoamine oxidase inhibitors b. SSRI’s and tricyclics (TCA) c. Opiates and MAOI d. All of the

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Biomedical Therapies: Electroconvulsive Therapy

303 Words | 2 Pages

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American Economy In The 1950's

166 Words | 1 Pages

The economy was prospering at enormous heights during the 1950’s. In order to keep the economy running smoothly, the promotion of low inflation was encouraged for people to continue buying goods. The American economy was strong and new businesses were sprouting up all over the country. As a result of these businesses, the job market stayed strong and Americans were high paid in relation to other industrialized countries. In the 1950’s the big motto of “buy now, pay later,” was what Americans followed, in which they bought goods such as houses, appliances, and cars on credit.

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Health Disparities In The United States

1677 Words | 7 Pages

The increase in antidepressants can be attributed to the increase of Americans who suffer from chronic stress. Many people today struggle in more than one aspect of their lives. The workplace, family, bills, health, and other factors can play a major role in inducing stress. These conditions can caused someone to feel defeated and ultimately affecting health, leading them to antidepressants. The increase of reflux medications is due to the increase of poor diets in America.

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1466 Words | 6 Pages

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2637 Words | 11 Pages

In 1991, amidst sharp conflict and controversy on the subject, an ad hoc committee consisting of ten medical experts from the Food and Drug Administration (FDA) voted unanimously to approve the use of Prozac and other selective serotonin reuptake inhibitors (SSRIs) within the United States for the treatment of various forms of depression amongst both adults and children. In the fifteen years that have followed, tens of millions of people have been prescribed these SSRIs, which today include Prozac, Zoloft, Paxil, Luvox, Celexa, Lexapro, Wellbutrin, Effexor, Serzone, and Remeron. These medications have been hailed as "wonder drugs" by many members of the medical community and are now the most common treatment for almost every form of depression.

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554 Words | 3 Pages

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876 Words | 4 Pages

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