Mouth Dissolving Tablets

Mouth dissolving tablets are a new and exciting alternative to traditional tablet and iquid medication dosages. Mouth dissolving tablets dissolve on the tongue, with the aid of saliva. Mouth dissolving tablets can dissolve in as little as 1 to 2 seconds or as long as 2 to 3 minutes, depending on the different fast dissolve/disintegration technologies used to manufacture them. Orally disintegrating tablets are an appealing dosage form for many reasons. Health professionals find the mouth disintegrating tablets as a good alternative for traditional tablets and liquid forms. Pediatric, geriatric, bedridden, and developmentally disabled patients are especially well suited for this alternative to traditional tablets. Medications used for treating

Mouth dissolving tablets are also called orally disintegrating tablets (ODTs), melt in-mouth tablets, porous tablets, oro-dispersible, quick dissolving and rapid disintegrating tablets3,4. Asthma is a disorder of variable intensity, typified by sentinel symptoms, airway obstruction, inflammation, and hyper responsiveness.5 About 300 million people worldwide suffer from asthma, with 250,000 annual deaths attributed to the disease. It is estimated that the number of people with asthma will grow by more than 100 million by 2025.6 Terbutaline Sulphate is used as a fast-acting bronchodilator which relaxes bronchial smooth muscle by selective action on β2 receptors7 it is used to prevent and treat wheezing, shortness of breath, and chest tightness caused by asthma, chronic bronchitis, and emphysema. It works by relaxing and opening the airways, making it easier to breathe.8 Due to sore throat conditions, the patient experiences difficulty in swallowing a tablet type of dosage form. Thus, fast disintegrating tablets would serve as an ideal dosage form pediatric patients who find it difficult to swallow the conventional tablets and capsules.9 hence an attempt was made for preparation of mouth dissolving tablet of Terbutaline Sulphate with an aim of providing rapid release and faster

It was observed that all the tablets pass the test for weight variation and content uniformity. Hardness of all tablets was between 2.5 to 3.5 kg/cm3, while the friability below 1%, all they have good mechanical strength. Water absorption ratio, & disintegration time of all batches were observed within 22 sec and 180 seconds respectively. It was found that as the concentration of sodium starch glycolate, and croscarmellose decreases, the disintegration time also decreases ,but when the concentration of sodium starch glycolate increase the disintegration time also increases, which may be because of gel formation. Tablets containing combination of sodium starch glycolate, croscarmellose & crospovidone showed 100% drug release within 10 minutes. It was observed that with the increase in concentration of superdisintegrants, the disintegration time decreased in following order: - Crospovidone > crosscarmellose > sodium starch glycolate.Faster dissolution was obtained when combination of superdisintegrants was used. Dissolution studies indicated, that tablets prepared by combination of three superdisintegrants showed rapid