Until recently necrosis has been thought of as random cell death, but after further research it has been found that it has more of a regulated system than what was originally thought4. Mitochondria are involved in a number of processes that regulates necrosis. These processes cause mPTPs (mitochondrial permeability transition pores) to open, this in turn causes the loss of the electron potential gradient and the dilution of the solute matrix solution resulting in the swelling of mitochondria5. The first protein Nix causes Ca2+ to be released from the endoplasmic reticulum, the Ca2+ is then transported into the mitochondrial matrix where necrosis can then be induced4. Proteins such as Bax and Poly(ADP-ribose) (PAR) can also initiate necrosis