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Nucleophilic Substitution Reactions

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Nucleophilic substitution reactions can be defined as reactions in which one nucleophile replaces another attached to a saturated carbon atom. A SN2 reaction occurs as a one step process also referred to as a second order due to its rate and is favored by 1°. For these reactions the intermediate is called pentavalent carbon because although there should never be more than four bonds on carbon, the nucleophile attacks as the same time the leaving group makes its way out causing the intermediate to have a broken bond with the leaving group while it forms a bond with the nucleophile. This is a bimolecular reaction, making the rate of a SN2 reaction dependent on the concentration of both the nucleophile and the substrate. The NaI acetone is a polar
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Experiment VIII was performed to analyze SN2 and SN1 using tertiary and primary substrates and use gas chromatography (GC) to examine the SN1 reaction. The product of the SN2 reaction was classified as n-butyl iodide by using infrared spectroscopy and gas chromatography mass spectroscopy and the product of the SN1 reaction was identified as of t-butyl chloride by using infrared spectroscopy and gas chromatography. For the SN2 reaction, 7.62 grams of n-butyl bromide, 20.0 grams of sodium iodide, and 79.1 grams of acetone were used to produce 3.12 grams of n-butyl iodide. The limited reagent was identified as n-butyl bromide and the theoretical yield of n-butyl iodide was calculated as 10.3 grams. The percent yield of this reaction was calculated

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Experiment 2 Report Scaffold (Substitution Reactions, Purification, and Identification) Purpose/Introduction 1. A Sn2 reaction was conducted; this involved benzyl bromide, sodium hydroxide, an unknown compound and ethanol through reflux technique, mel-temp recordings, recrystallization, and analysis of TLC plates. 2. There was one unknown compound in the reaction that was later discovered after a series of techniques described above.

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It is understood the mechanism is acid-catalyzed where protons coordinate with the carbonyl oxygen to make the carbonyl carbon more electropositive for nucleophilic attack (Scheme 1). In the experimental procedure all reactants were added together, this is inefficient as the protons can coordinate with either trans-cinnamic acid or methanol. Coordination with methanol is unnecessary as it reduces its nucleophilicity and makes less protons available to coordinate with the carboxylic acid. To improve

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This pushes the carbonyl’s electrons onto the carbonyl carbon, while the Histidine-57 takes one proton from the

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My Element villain's name is plutonumous and his main element is plutonium. I decided to pick plutonium out of all the elements of the periodic table because it is known to be the most dangerous element and that's what villains are “dangerous”. My villain looks really generous, brilliant and strong since he is covered with layers of plutonium as well as plutonium in his veins this is done to his advantage because plutonium has a very high melting point so he could go through fire without being hurt, he also has really big eyes that glow green to make him look scary they become red depending on his mood, he has normal mouth since that doesn't really grant him any advantages however he's got really big ears so his hearing could be very precise

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The purpose of this experiment was to learn about the electrophilic aromatic substitution reactions that take place on benzene, and how the presence of substituents in the ring affect the orientation of the incoming electrophile. Using acetanilide, as the starting material, glacial acetic acid, sulfuric acid, and nitric acid were mixed and stirred to produce p-nitroacetanilide. In a 125 mL Erlenmeyer flask, 3.305 g of acetanilide were allowed to mix with 5.0 mL of glacial acetic acid. This mixture was warmed in a hot plate with constantly stirring at a lukewarm temperature so as to avoid excess heating. If this happens, the mixture boils and it would be necessary to start the experiment all over again.

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There are several different reactions that can be used to synthesize an alkene product, however the main reaction being utilized for this experiment is the Wittig reaction and the Horner-Wadsworth-Emmons modification. The Wittig reaction involves a reaction between an aldehyde or ketone and ylid, which is also referred to as the Wittig reagent. The Wittig reagent is synthesized from a phosphonium salt and a strong base (Wittig Reaction, 2006). The reaction between the Wittig reagent and the ketone or aldehyde is a nucleophilic substitution; the carbon double bonded to the oxygen in the carbonyl is replaced with a carbon double bonded to another carbon (University of Liverpool, 2008).

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The objective of this experiment was to use an aldol condensation reaction to synthesize 3-nitrochalcone from 3- nitrobenzaldehyde. This was accomplished with a Diels-Alder reaction that utilized 3-nitrobenzaldehyde, acetophenone, ethanol, and sodium hydroxide. The mechanism for the synthesis of 3-nitrochalcone is presented in Figures 1 and 2. The alpha carbon on the acetophenone is deprotonated. This is followed by the attack of the alpha carbon anion on the carbonyl carbon on the 3-nitrobenzaldehyde.

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Aims of experiment • Determine the rate constants for hydrolysis of (CH3)3CCl in solvent mixtures of different composition (50/50 V/V isopropanol/water and 40/60 V/V isopropanol/water) • Examine the effect of solvent mixture composition on the rate of hydrolysis of (CH3)3CCl Introduction With t-butyl chloride, (CH3)3CCl, being a tertiary halogenoalkane, it is predicted that (CH3)3CCl reacts with water in a nucleophilic substitution reaction (SN1 mechanism), where Step 1 is the rate-determining step. The reaction proceeds in a manner as shown

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802 Words | 4 Pages

“Diazotization of L-phenylalanine results in the unstable aliphatic diazonium salt 2, which is believed to undergo a rapid, intramolecular SN2 reaction to give the highly strained R-lactone (3) (3)”. “In a second, slower, intermolecular SN2 reaction, 3 reacts with the solvent (water) to open the lactone and yield the final product, (S)-2-hydroxy-3-phenylpropanoic acid (4)”. “Because this process occurs with two SN2 reactions, the final product has a net retention of configuration”. “This reaction has the added advantage of being environmentally friendly: the reaction is run in aqueous solution, using a safe amino acid and generates no hazardous waste requiring disposal”. “This experiment illustrates some important chemical concepts, including: Water solubility dependence on the state of ionization of a compound, Stereospecificity of the SN2 reaction, Measurement of optical activity, Effect of diastereotopic protons in the 1 H NMR spectrum”.

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Chemical reactivity measurement of test chemicals towards nucleophiles is getting more attention as an alternative to animal method in testing for potency of skin sensitizers. In view of this, alternative methods are expected to be highly reproducible. To achieve this, there is need for proper investigation of appropriate method of analysis. Depletion of protein nucleophiles and formation of covalent adducts between skin sensitizers and dermal proteins are very important processes in skin sensitization. These are monitored and detected through various means like ultraviolet-visible spectrophotometry, high performance liquid chromatography/mass spectrometry (HPLC-MS), liquid chromatography/mass spectrometry (LC-MS), nuclear magnetic resonance/mass spectrometry (NMR-MS), etc.

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Links between many dream related By Alex Kent theories and Inception In this essay I will be looking at whether Inception supports Freud’s Dream Theory or the Activation Synthesis Theory. I will be analysing multiple scenes that promote their corresponding theory. These can be the likes of external dream influences, Freud’s many theories or the Activation synthesis theory In my first analysis it is not of a scene but of a concept in the movie.

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During this step, this energy is used to produce ATP. The acetyl CoA made in the last step combines with a four-carbon molecule and goes through a cycle of reactions, ultimately regenerating the four-carbon starting molecule. ATP, ext {NADH} NADHN, A, D, H, and text{FADH}_2FADH2F, A, D, H, start subscript, 2, end subscript are produced, and carbon dioxide is released.

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It is never used up in the chemical reaction, however it is recycled and used over and over again. Description Metabolic pathways are controlled by the presence or absence of particular enzymes in the metabolic pathway and also through the regulation of the rate of reaction of key enzymes within the pathway [1]. Each enzyme required for a step in metabolic pathway is a central point of control of the overall metabolic pathway. Without the specific enzyme to catalyze a reaction, the metabolism would be too slow to support life and the pathway cannot be completed [2].

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The isomers which can be inter converted solely by rotation about formally single bonds in a form of stereoisomerism in chemistry studies are defined as conformational isomers. This phenomenon in chemistry is called as conformational isomerism. Conformational isomers are stereoisomers which arise from the rotation about sigma (σ) bond (single bond). It is usually fast interconverting in room temperature, causing in different arrangements of atoms in three-dimension space. The isomers which created in the specific conformational isomerism can be referred as conformers, or pointedly as rotamers.

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