There is a significance between the poem, "To a Mouse," by Robert Burns and, "Of Mice and Men," by John Steinbeck. The poem," To a Mouse", is about a mouse that builds a nest in the winter, in a wheat field, only for it to be destroyed by a plough. The novel, Of Mice and Men is about two friends, George and Lennie, who are ranch workers during the Great Depression. When the plough man destroyed the mouse 's warm place, he faced nothing but grief and pain. In the text, "The best laid schemes of mice and men. Often go wrong. And leave us nothing but grief and pain." Robert Burns shows his theme as loneliness. In Of Mice and Men, the theme was also loneliness. For example, in the novel, George said to Lennie, "Guys like