The Columbian exchange was obviously a huge part of American history, and had huge impacts for both the European colonists and the Native Americans. The appearance of the colonists had both negative and positive effects on the native people, while the native people as well created benefits and setbacks for the Europeans. Diseases such as smallpox, influenza, and malaria killed many Native Americans. The natives immune systems were not strong enough to handle them. The Europeans were also affected by disease, as they had never been exposed to some illnesses that the Native Americans passed on to them, such as syphilis. The diseases were the most negative side effects of the Columbian exchange. However, there were also some positive things that