The arrival of Old World populations in the Americas in the sixteenth and seventeenth centuries brought about significant biological changes that had far-reaching effects on the indigenous peoples of the region. The Columbian Exchange, as described by Alfred Crosby, refers to the transfer of plants, animals, and microorganisms between the Old and New Worlds following Columbus's arrival in 1492. While this exchange had both positive and negative effects, the negative effects were particularly significant for indigenous Americans, who were ill-prepared for the new diseases, food scarcities, and abundance that came with the arrival of Europeans and Africans. This essay will explore these effects in greater detail, examining how they transformed the lives of Indians and contributed to the depopulation and marginalization of indigenous communities. …show more content…
The most infamous of these diseases was smallpox, which was introduced to the Americas by Europeans in the early sixteenth century. The disease spread rapidly among indigenous populations, causing widespread death and depopulation. Estimates suggest that as much as 90% of the indigenous population of the Americas died from diseases introduced by Europeans and Africans. In addition to smallpox, other diseases such as measles, influenza, and typhus also had a devastating effect on indigenous communities. The impact of these diseases was compounded by the fact that many indigenous communities lacked the infrastructure and medical knowledge necessary to respond effectively to epidemics. The result was a dramatic decline in the population of indigenous Americans and a significant alteration of their social, cultural, and economic