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Radiolabel Inflammatory Bowel Disease Case Study

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Introduction Radiolabel can be called radiotracer marker or radioactive pharmaceutical agent which is commonly used in therapeutic or diagnostic purpose. Radiolabel applied on white blood cell has different procedure and precautions as well as different diagnostic area in hospital. Radiolabel which applied in clinical practice is on certain type of cells which are red blood cell, white blood cell and platelet. The radioactive agent commonly used to radiolabel the white blood cell include 99mTc -HMPAO and 111In-oxine. Technetium-99m is used in the blood or injected into patients systemic circulation so that it can be detected by medical equipment such as X-ray. Technetium exametazime under brand name of Ceretec which commonly perform radiolabel …show more content…

Crohn's disease and ulcerative colitis are the most common inflammatory bowel disease. The causes of Crohn's disease can be genetic, exposure of microbes, environmental factor as well as immune system. The symptoms include onset of diarrhoea, abdominal pain and bloody faeces. It can be classified into colic, ileocolic and ileal. There is also classification by action of the disease such as stricturing, penetrating, and inflammatory. Stricturing disease leads to narrowing of the bowel that may lead to obstruction of bowel. Penetrating means uncommon passage path in the bowel . Inflammatory disease means inflammation action without bringing strictures or fistulae. Ulcerative colitis is another chronic disease related to the large intestine or colon which include inflammation of colon lining which grow sores and ulcers. Ulcerative colitis can occur due to an unusual immune system response. In radiolabeling , CT scan is useful to determine the presence of abscesses, fistula and perforations in gastrointestinal system. Extra information can be obtained by Scintigraphic imaging about the progress of the disease. It screens the needs of further treatment or diagnostic procedure. Treatment monitoring, disease progress, other complications can be done by labelled white blood cell imaging. Both 111In and 99mTc can be used in label white blood cells. Single photon …show more content…

However, it has high cost and difficult to prepare as well as low availability. It has the ability to accumulate in spleen with blood-half clearance time of 7 hours which reduce the time needed for imaging and diagnostic procedure (Datz, 1996). By the way, it brings out inconvenience when several parts of inflammation occur at the same time because of the nonspecificity of leukocytes for infection. Therefore it is favoured during the diagnose of organ inflammation include kidneys, bladder, and for chronic infection

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Crohn's Disease Crohn’s Disease is a disease that causes inflammation in the small intestine. Millions of people all over the worldwide are suffering from Crohn’s Diseases. In 1932, Crohn’s Diseases was referred to as a medical illness and it was described by Dr. Crohn, Dr. Leon Ginzburg, and Dr. Gordon Oppenheimer. But it all started in 1913 by a physician named Kennedy Dalziel who had a meeting with the British Medical Association, and described his nine cases with patients who suffered from intestinal obstruction. One day with a close examination of the inflamed bowel of a patient, the transmural inflammation that is characteristic of the disease was clearly evident.

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Crohn 's is an immune-mediated inflammatory disease that belongs to a larger group of illnesses called inflammatory bowel disease (IBD). It is associated with inflammation of the digestive tract, or gastrointestinal (GI) tract, which runs from the mouth to the anus, and includes the stomach and intestines. It more commonly affects the end of the small intestine and the large intestine. Crohn 's disease symptoms and complications are unpredictable , you may experience almost no symptoms, then have a sudden flare-up. Or you could experience symptoms every day Crohn 's disease is difficult to diagnose, because symptoms vary and because it can be similar to other conditions.

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My dad and I have Crohn’s disease. My dad has a very severe case and although many different types of medications exist for Crohn’s, he is allergic to many of them. In the nineties, the only prescription he could take was prednisone-you were not supposed to stay on that long term. As a result of this, he had a multitude of different health problems that stemmed from the long-term use, some including him being on crutches due to blood loss in his legs and he also had to have to get six feet of his intestines cut out. Due to medical innovations such as Remicade and other biologic therapies and monoclonal antibodies, my dad was able to reach a stable state.

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Ans. Let us first understand the difference between Crohn’s Disease and ulcerative Colitis. These are different factors or let us say distinction between the ulcerative colitis and the Crohn’s disease. We have distinguished them in four categories such that a person is able to get a basic difference between these two and then in turn work out the disease of our patient.

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The thing that I’m most activity involved in a positive way is also the thing that has been the most negative thing in my life. When I was a freshman in high school I got diagnosed with Crohns. You might be wondering how an event can be both a positive and a negative thing in my life. I spent along time dealing with that exact question. I finally came up with an answer, the reason it’s both positive and negative… before I tell you that let me explain a few things.

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I would always have to deal with stomach aches and live in constant fear that those stomach aches were not more ruptured intestine. I would also have to take medicine every day twice a day, something I had never had to do. Worst of all, it was forever, there was and is no cure for Crohn’s disease.

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Crohn’s disease is most prevalent in developed countries like the United States, the United Kingdom, Australia, New Zealand and Scandinavia. The occurrence of this disease is less in developing regions of the world due to the root causes - mainly genetic and being triggered by food habits (more dependence on animal protein in developed countries while in less developed countries a lot more animal protein is consumed) and environmental reasons. Crohn’s disease has been a major problem since the beginning of World War 2 when it was first discovered. The disease has claimed the lives of over two hundred thousand Americans, and has infected almost 1.6 million since 1943. The number of people who have been diagnosed with this disease has increased

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Depending on where the inflammation occurs within the large intestine UC is classified by how far the disease extends up the colon. Research has shown that genes, the environment, and an overactive immune response could play a role in causing UC unfortunately, the exact cause of the disease is not known. “Research sponsored by CCFA has led many scientists to believe that ulcerative colitis may be the result of an interaction of a virus or bacterial infection of the colon and your body’s natural immune system response”(Crohn’s & Colitis Foundation of America, 2015). Although research has not be able to pinpoint the exact cause of Ulcerative Colitis it can actually occur in people of any age. Nonetheless, research has shown that it hoes have a higher occurrence rate in people between the ages of 15 and 30, who have family members with Inflammatory Bowel Disease, and who are of Jewish

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When I was first diagnosed with ulcerative colitis, a common colon disease, I had no idea what it was. It wasn’t until several tests and explanations from multiple doctors that my parents and I started to understand the extent of the problem. Although it didn’t seem like it would be a big deal, it quickly took over my entire life. Dealing with the condition meant chronic pain, medication, and many more doctors’ visits. Fortunately, my case wasn’t too severe.

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There were times when Crohn’s had overpowered by life. By that, I mean Crohn’s was first and I was controlled by it, not it by me. I

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There’s nothing worse than waking up to find yourself a bloody, gassy mess. There’s also nothing worse than waking up in a hospital and seeing your doctor’s face, but the worst is learning that you have ulcerative colitis. After months of constant stomach aches and diarrhea, I finally had an answer. Ulcerative colitis.

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