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Glycol Synthesis Lab Report

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Rose Bengal-(bis(aminoethyl)ethylene glycol) (2) from Rose Bengal disodium salt (1)
The synthesis was done following procedure from [15]. Rose Bengal Na+ salt (915 mg, 0.90 mmol) was dissolved in DMF (2ml) and DIPEA (0.312 ml, 1.80 mmol), HATU (308 mg, 0.81 mmol) were added. After activation for 15 min, the mixture was added to O-Bis-(aminoethyl)ethylene glycol trityl resin (309 mg, 0.31 mmol) preswollen in DMF for 2 hours. The coupling reaction wrapped in aluminum foil was allowed to proceed overnight on a nitrogen bubbler apparatus. The resulting red-burgundy coloured resin was filtered and washed well with DMF. The resin was treated with 20% piperidine in DMF to hydrolyze any unwanted acylation on the phenolic hydroxyl groups. The resin …show more content…

The solution was stirred at room temperature for 8h. The solvent was blown out with nitrogen. The residue was added to 1 ml of water containing 0.1% TFA and purified on RP-HPLC. Massspec of the final product clearly indicates presence of RB modified on PEI by series of peaks matching different polymer compositions (see Fig. 6).

RP-HPLC program:
0-5 min
5-30 min
30-35 min
20% MeCN
20-85% MeCN
85-99% MeCN

5-{3-(3-N-polyethyleniminemaleimide)propylamidophenyl}-10,15,20-tris(4-sulfonato-phenyl)porphyrin trisodium salt (TPPS-PEI) (8b)
TPPS-Mal (20 mM) in 500 μL of dry DMF was titrated to 500 μL of 40 mM polyethylenimine in dry DMF. After stirring at room temperature for 8 h additional 0.5 ml of 40 mM PEI were added. The solution mixture was kept with stirring overnight. The solvent was removed under reducing

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The yellow solution containing the reactants was slowly poured into the beaker containing the cold water and the acid in order to cause the precipitation of the alcohol, 9-fluorenol and to destroy (hydrolyzed) the unreacted excess sodium borohydride. Subsequently, the white precipitate was vacuum filtered and washed twice with 20.0 ml portions of distilled cold water by pouring the liquid into the Buchner Funnel during filtration. It was necessary to wash the alcohol prior to recrystallization considering that the C-OH bond is easily broken by the formation of a stable and benzylic carbocation that favors the synthesis of difluorenyl ether. Finally, before the purification by recrystallization of the obtained product, the white solid alcohol was allowed to dry over a period of a

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704 Words | 3 Pages

Lab Report 5: Acetylsalicylic Acid (Aspirin) Synthesis Name: Divya Mehta Student #: 139006548 Date Conducted: November 19th 2014 Date Submitted: November 26th 2014 Partner’s Name: Kirsten Matthews Lab Section: Wednesday 2:30 L9 IAs Name: Brittany Doerr Procedure: For the procedure, see lab manual (CH110 Lab Manual, Fall 2014) pages 96-98. Wilfrid Laurier University Chemistry Department. Fall 2014. Acetylsalicylic Acid (Aspirin) Synthesis.

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The product obtained was (2S, 3R)-2, 3-dibromo-3-phenylpropanoic acid and (2R, 3S)-2, 3-dibromo-3-phenylpropanoic acid, which are enantiomers. This was determined through melting point analysis. The melting point range for the product was 198 to 202 degrees Celsius, which is a lot close to the given melting point of the anti-addition product, 202-204 degrees Celsius. The given melting point range was 93.5-95 degrees Celsius. Furthermore, the syn-addition product is unlikely and difficult to produce due to stereochemistry selectivity.

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753 Words | 4 Pages

This also means that the impurity, 1, 4-dibromobenzene, was not probably extracted completely; it should have been removed during vacuum filtration. However, all the steps for carrying out the extraction of the neutral compound was successful; there were no complications. The error must have occurred during the crystallization procedure. 95% Ethyl alcohol was used as the solvent to dissolve the

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481 Words | 2 Pages

To a stirred solution of acetanilide (2gm, 0.5moles) in dry acetonitrile (5ml) at 0-5⁰C, TiCl4 (2.8gm, 1.0moles) was added drop wise with stirring and the mixture was stirred at room temperature for 30 min. Then Sodium azide (0.93gm, 0.5 mol.) was added to it and the reaction mixture was heated at 80-90⁰C. After 2 hrs remaining amount of sodium azide (0.93gm, 0.5 mol.) was added to reaction mixture and heating was continued for 4-6 hrs. The reaction was monitored by TLC after 3hrs. Then the reaction mixture was cooled and poured over crushed ice and the product separated out was filtered, washed with water, dried and recrystallized from alcohol. 5-Methyl-1-phenyl-1H-tetrazole (1).

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1111 Words | 5 Pages

2. a) The main form of sugar found in the blood is blood glucose. When there are high amounts of sugar in the blood, glucose-1-phosphate is converted into glycogen as a store of carbohydrates through glycogen synthase. Glycogen synthase is an enzyme that converts glucose into glycogen in an energetically favorable reaction.

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360 Words | 2 Pages

Toxins are present in everyday life in a variety of places. Ethylene glycol, commonly found in antifreeze and other household products. Ethylene glycol can be toxic to humans, as well as pets. With antifreeze founds in many households, it is common for pets to find and ingest this toxin. Commonly found in garages where antifreeze is kept, the sweet tasting liquid is often was entices pets to drink it up.

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529 Words | 3 Pages

Propylene Glycol Propylene Glycol is found in antifreeze, it is a humectant which means it is hydrating but is also a skin irritant. It is widely found in skin care products such as body washes, deodorants, shampoo, conditioner and liquid for e-cigarettes. This is because it is cheaper for companies to add this to their products rather than using botanical ingredients. By adding Propylene Glycol it prevents the product from spoiling in hot and cold temperature and helps products to sink into the skin. Although Propylene Glycolic can work into the blood stream.

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814 Words | 4 Pages

There are two turns of the Krebs cycle for each 6C glucose input. Furthermore, when computing the possible net ATP yield, two link reactions and a Glycolysis must considered. There is a probable yield of 38 molecules of ATP from the breakdown of one glucose molecule in aerobic respiration. Simply put, glucose is a large stable molecule with lots of chemical energy trapped in its bonds. It is easy to release this energy explosively, say, by combustion; but that would damage the cell, and most of the energy would be lost as useless heat.

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1480 Words | 6 Pages

The synthesis was carried out in an aqueous medium by microwaves using olibanum gum (Boswellia serrate) as a reducing and stabilizing agent without using any harsh, synthetic reducing agents. The greener synthesis of olibanum gum capped AuNPs was found to be eco-friendly due to the utilization of renewable plant material. The amount of gum and irradiation time effect the formation of NPs. Microwave irradiation can accelerate the formation of NPs and as the concentration of gum increases, the particle size decrease. The designed olibanum gum capped AuNPs are highly stable, and have shown effective catalyst in the reduction of 4-NP to 4-AP and electron transfer reaction between K3[Fe(CN)6] and NaBH4.

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1463 Words | 6 Pages

SUMMARY AND CONCLUSION Rheumatoid arthritis (RA) is an auto- immune disease (Giofsky et al., 2012) in which immune system of body by mistake attacks the healthy tissues especially the joints and their surrounding tissues. It is a chronic, systemic inflammatory disease affecting approximately 0.5% of the population. Rheumatic arthritis is more common in women and may occur at any age, with peak incidence at ages 50 to 60 years. The most prominent feature is symmetrical joint swelling of the feet, hands, and knees, although any joint (Tunr et al., 2010).

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1252 Words | 6 Pages

Power in anaerobic conditions represents an expression of strength at speed (strength/speed = power) measured in Watts (W) (Draper and Marshall, 2014). Glycolysis is a 10-step process in which the breakdown/catabolism of glucose occurs to synthesize/produce ATP (Adenosine Tri phosphate) otherwise known as energy for the body. Glycolysis produces a lot of power and is the predominant energy system for maximal effort lasting between 30 seconds to 2 minutes (Karp, 2009). It has been estimated in a study by Baker, McCormick and Robergs (2010) that over a 30 second sprint glycolysis accounts for 49% of energy production, and over a 10 second sprint 44%. During a single short sprint (5-6 second) Glaister (2005) states that ATP is resynthesized from

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1036 Words | 5 Pages

Glycerol is an organic compound that consists of three-carbon chain with a hydroxyl group attached to each carbon and it is physiologically harmless [1]. Glycerol has the following of physical and chemical properties such as high boiling point, negligible vapor pressure, does not require special handling or storage and compatible with most organic and inorganic compounds. Glycerol is a trivalent alcohol with many commercial applications, presently finding its largest use in the pharmaceutical, food, cosmetic and chemical industries [2]. Glycerol also can be employed as the raw material to produce variety types of chemical products such as hydrogen, ethanol, propanol, acrolein, 1,3- propanediol, lactic acid, succnic acid, citric acid, polyesters

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The residue was reconstituted in 50 µL of mobile phase and 30 µL were injected onto the HPLC

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Introduction to glycogen and glucose Glycogen is a multibranched polysaccharide of glucose that serves as a form of energy storage in animals and fungi. The polysaccharide structure represents the main storage form of glucose in the body. In humans, glycogen is made and stored primarily in the cells of the liver and the muscles hydrated with three or four parts of water. Glycogen functions as the secondary long-term energy storage, with the primary energy stores being fats held in adipose tissue.

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