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Side Effects Of Schizophrenia

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Researchers in Toronto, Canada have discovered an innovative drug target that has opened up new possibilities for the treatment of Schizophrenia.
Patients with schizophrenia are currently treated with antipsychotic drugs that interfere or completely block the receptor for a neurotransmitter called Dopamine. The blocking of this D2 receptor, however, causes side effects that are unwanted. These side effects include a tremor, muscle spasms and more serious side effects such as diabetes or tardive dyskinesia (involuntary movements of the face and jaw). These side effects can become so severe that it can discourage patients to not take their medication, which impacts recovery. Schizophrenia is an increasing problem; with around 1% of the general
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Thus, medication is an extremely influential environmental factor that directly impacts the lives of people with schizophrenia

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Prescription drugs pose many health risks including both short term and long term side effects. Every prescription information sheet from any local pharmacy lists a plethora of warnings, cautions, and possible side effects. In many cases, the patient is forced to wonder if the prescription drug will help their illness, or cause further medical issues. Side effects that are considered “mild” are still troubling. Side effects such as drowsiness, sleeplessness, muscle pain, dizziness, nausea and bouts of depression may not appear to be harmful but can cause serious consequences.

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The dopamine hypothesis refers to an excess amount of activity in dopamine synapse in the brain to be the cause of the positive symptoms of schizophrenia. This theory explains why typical antipsychotics only treat the positive symptoms of schizophrenia because the D2 receptors are blocked, leading to less activity in the dopamine synapses. Atypical antipsychotics, also block D2 receptors but also blocks as specific subtype of a serotonin receptor called the 5HT2A receptor. Studies show that the combined blockage at the D2 and 5HT2A receptors treats both the positive and negative symptoms of schizophrenia. Since both the D2 and 5HT2A receptors are blocked, atypical antipsychotics treat both the positive and negative symptoms of schizophrenia.

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The cognitive symptoms might be hard to perceive as a feature of this disorder. the cognitive deformities of schizophrenia are predictable with a far-reaching disturbance in cerebral capacity and discernment. Variations from the norm of a cerebral blood stream appropriation in patients with unending schizophrenia. Also, the researchers surmise that an unevenness in the unpredictable, interrelated synthetic responses of the cerebrum including the neurotransmitters dopamine and glutamate, and potentially others, assumes a part in schizophrenia. The brain structures of a few people with schizophrenia are marginally not the same as those of healthy individuals.

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