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Stereotypes Of Aminocentesis

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Amniocentesis has been widely used since it was first performed in 1956[1]. Originally reported as a method of determining fetal sex in utero, Fuchs and Riis then hypothesized that it could be possible to diagnose chromosomal abnormalities in utero via this technique. By 1963, it had been confirmed that the karyotype of fetal and amniotic cells are identical[2]. Steele and Brag then showed in 1966 that amniotic cells can be sampled and cultured in sufficient quantity to be karyotyped, showing that in utero chromosome analysis was possible[3]. Shortly thereafter, the first prenatal diagnosis of an abnormal karyotype was reported[4]. Since that time, its utility has only continued to expand in both the second and third trimesters. In 1979,

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