High-school senior Peter Parker lives with his Aunt May and Uncle Ben, and is a school outcast. On a school field trip, he visits a genetics laboratory with his friend Harry Osborn and love interest Mary Jane Watson. There, Peter is bitten by a genetically engineered "super spider." Shortly after arriving home, he becomes unconscious. Meanwhile, Harry's father, scientist Norman Osborn, owner of Oscorp, is trying to secure an important military contract. He experiments on himself with an unstable performance-enhancing chemical. After absorbing the chemical, he goes insane, and kills his assistant.
The next morning, Peter finds that he is no longer near-sighted, and his body has metamorphosized into a more muscular physique. At school, he finds
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He enters an underground fighting tournament and wins his first match, but the promoter cheats him out of his money. When a thief suddenly raids the promoter's office, Peter allows him to escape. Moments later, he discovers that Ben was carjacked, and killed. Peter pursues and confronts the carjacker, only to realize it was the thief he let escape. After Peter disarms him, the carjacker flees, but dies in the process. Meanwhile, a crazed Norman interrupts a military experiment, and kills several scientists and the military's General …show more content…
Harry, who loves Mary Jane, arrives and learns she has feelings for Peter. Devastated, Harry tells his father that Peter loves Mary Jane, unintentionally revealing Spider-Man's biggest weakness.
Norman holds Mary Jane and a Roosevelt Island Tram car full of children hostage alongside the Queensboro Bridge. He forces Peter to choose whom he wants to save, and drops Mary Jane and the children. Peter manages to save both Mary Jane and the tram car, while Norman is pelted by civilians who side with Spider-Man. Norman then grabs Peter and throws him into an abandoned building where they battle. When Norman boasts about how he will later kill Mary Jane, an enraged Peter overpowers Norman.
Norman reveals himself to Peter, who stops attacking. He begs for forgiveness, but at the same time controls his glider to impale his foe. Sensing the attack, Peter dodges, and the glider impales Norman. As he dies, Norman begs Peter not to tell Harry of Norman's identity. Peter takes Norman's body back to his house. Harry arrives to find a costumed Peter standing over his father's body. He seizes a gun, intent on shooting Peter, but Peter escapes and hides Norman's