The official definition of the word "friend" is, and I quote, "a person whom one knows and has a bond of mutual affection with." This statement is true; however, it only vaguely expresses the standards of a friend. Self-sacrifice, being genuine and honest towards one another, and mutual trust all come together to form an absolute true friendship, and are conveyed in popular media, such as Harry Potter and Grey's Anatomy.
In the Harry Potter book series, the protagonists seem like an ordinary bunch of friends in the beginning. They laugh, joke, stick together, and are overall good friends. Their personalities are clearly shown to one another, and they never try to hide who they are. However, as the books progress and the underlying theme of death and destruction becomes more prominent, the characters' view towards one another changes. When one of the lives of the characters is threatened, they are willing to sacrifice themselves for one another, and trust each other with information that could potentially harm the world around them. Indeed, in those moments, the trueness of their friendship is defined and proven.
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At first glance, their bond seems to be basic and barely skimming the surface of the word true, especially in the beginning of the series. But, their friendship flourishes and progresses in time. For example, when Cristina is left at the altar by her fiancée, everybody dismisses her as being insane and leaves her distraught and broken. However, unlike the majority, Meredith comforts her, and Cristina confides in Meredith all of her sorrows and regrets. The two can trust each other with something as simple as a rumor going around, or something as complex as a hidden pregnancy. Admittedly, the relationship doesn't go to the point of sacrificing lives, but it serves as an example of what a modern day serious friendship looks