In September 2004, a 17 year old girl was diagnosed with Type 1 Diabetes Mellitus in Craigavon Area Hospital. She presented with key symptoms of hyperglycaemia, tiredness, blurred vision and an increased thirst and polyuria. She also displayed signs and symptoms of ketoacidosis at the time of diagnosis. HBA1C analysis and glucose test results also supported the diagnosis.
She was diagnosed with Type 1 diabetes mellitus and began treatment management of her glucose levels by administration of frequent insulin injections throughout the day on a basal bolus regime. Initially, this included 19 units of Novorapid throughout the day before meals and 6 units of Insulin Glargine (Lantus) at night time. This managed the patient’s glycaemic level
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It was brought to attention of the diabetologist that the patient had a very strong family history of diabetes; with the patients mother, sister, brother, two cousins and several aunts and uncles diagnosed with diabetes in their late teens/early 20’s. Several of these family members were diagnosed with Type 1 diabetes, which usually presents early on in life, in comparison to Type 2 which generally arises due to lifestyle factors in later years. Diagnosis of Type 1 Diabetes becomes increasingly uncommon in individuals in their late teens and twenties, making this particular case relatively unusual. Taking into account the requirement for very low doses of daily insulin and the strong family history of diabetes mellitus, further investigations were undertaken. In order to exclude rarer variations of diabetes such as Maturity Onset Diabetes of the Young, a post-prandial urinary C-Peptide: Creatinine Ratio test was requested to assess endogenous insulin secretions.
Background:
Diabetes Mellitus (DM) is a collection of metabolic diseases in which individuals experience high levels of blood sugar known as hyperglycaemia, along with associated symptoms. The most common forms of diabetes mellitus include Type 1 DM, Type 2 DM and Gestational DM, each presenting with hyperglycaemia at different stages of life. Other associated conditions include Neonatal