Clusiaceae Essays

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reasons for withdrawal of terfenadine from the market in 1998. Grapefruits showed significant CYPs mediated interaction with several drugs (specifically CYP3A4 substrates) (Wanwimolruk et. al., 2014). St. John's wort (Hypericum perforatum L.; family Clusiaceae) is a popular medicinal herb, widely used for the treatment of depression and anxiety. On chronic use, It affect the pharmacokinetic of several drugs (cyclosporine, theophyllin, warfarin, oral contraceptives, digoxin, indinavir and clopidogrel)