Inverse agonist Essays

between a) an agonist and antagonist –give 2 examples of each When the action of the drug is to activate or switch on a reaction, the drug is called an agonist. On the other hand, if the drug switches off the reaction, or inhibits or blocks the binding of other agonist components onto the receptor, it is called an antagonist. Hence, agonist and antagonist act in opposite direction, if agonist activate an action, antagonist inhibit an action(New Health Guide, 2014).Besides, agonist is imitates the

MODAFINIL:DRUG OF THE MODERN ERA Modafinil(commonly known by the brand names Provigil, Alertec, Modavigil etc) is an oral drug that is used to induce wakefulness in patients with sleepiness. It reduces fatigue and enhances alertness in an individual. It is also known as nootropic. It is usually taken once in a day with or without eating your meal. Modafinil is approved by the U.S. Food and Drug Administration for the treatment of narcolepsy or Obstructive sleep apnea hyperpnoea syndrome (OSAHS)

A good man is hard to find is about a family who are planning to travel to Florida. The whole family is excited to go except the grandmother, who doesn’t want to go. To make her case, she tells her son Bailey, his wife, and their three children that there’s a criminal named the Misfit headed to Florida. The Misfit is one of the main characters in the story. The author, Flannery O’Connor, introduces him explaining his background and motivations. In doing so, she portrays a character that is both mythical

Physical Activity Log Assignment Name Institution Physical Activity Log Assignment 1. Introduction – Describe the significance of monitoring physical activity, setting goals, and evaluating results. It is always important to set goals and to monitor them. These activities help people to have a productive and fruitful lifestyle. Monitoring and evaluation are examples of self-management (Health.gov, 2014). Self-management and self-monitoring is the process of understanding and looking at one’s

In the story “ The Devil and Tom Walker” by Washington Irving, the theme of greed is exaggerated through Tom Walker’s life story. Throughout the story, Walker’s estranged and miserly relationship with his wife, his self-beneficial life choices that harm others, and his unfortunate and pitiful death, demonstrate horrible occurrences in a greed-filled lifestyle. Irving also elucidates to readers that consistent desires and the feelings of dissatisfaction towards everything will eventually lead to an

The book Full House: An Invitation to Fractions is written by Dayle Ann Dodds and illustrated by Abby Carter. By incorporating this piece of literature, one can creatively introduce second or third grade students to the world of fractions. The illustrations are creative, bright, and enjoyable to look at as the story is being read. The use of rhyme and rhythm makes the book easy to read and fun to listen to. Join Miss Bloom as she runs the Strawberry Inn to learn about fractions as she works

Conflict is a process in which one party perceives its interest are being opposed or negatively affected by other party. Based on the movie “Devil wear Prada” there are many conflicts involved in this movies. The three conflict involved in this movie are personality conflict, intergroup conflict and also programmed conflict. o Personality conflict Personality conflict or also known as intrapersonal conflict occurs within an individual. The experience takes place in the person’s mind. Hence, it is

The Best Inversion Table Exercises To Try Right Now To be completely honest, no one’s quite sure who invented inversion therapy. Poke around on the internet and you’ll find pictures of spinal-stretching contraptions that date back to the Hippocratic time of 460 BC. I’ll admit, a Hippocratic bench looks too much like a torture device, but an inversion table is a different story. They just look sporty. In short, an inversion table uses gravity to decompress the spine and gently stretch the muscular

Jamila Hoque Golam Rabbani Shihab English-520 2016-2-93-008 Antonio Gramsci’s Hegemony in Don DeLillo’s novel White Noise This study delineates the use of cultural hegemony in Don DeLillo’s White Noise through the vintage points of Italian critic Antonio Gramsci (1891-1937) who clarifies domination of the ruling class over ruled class. Cultural Hegemony is the mastery of the middle class and governing groups among the lower divisions. Antonio Gramsci declares that the only means of keeping cultural

1. Disney Introduces Demand-Based Pricing at Theme Parks Source: Barnes, B. (2016) [Disney has decided to make seasonal changes to ticket prices. The prices are raised during holidays and weekends as there is a high demand for tickets and the company will make an increased profit. The price of the tickets will vary at different theme parks.] A type of pricing strategy [On a general note, at the Disneyland located in California, regular tickets will be sold for $105 on weekends when more people

a) What it is the opportunity cost of producing an additional bowling ball measured in terms of forgone bicycles in western Leisureland? Western Leisureland can produce at max 100 bicycles or 400 bowling balls. If you create a graph to illustrate the production possibilities, with bikes on the vertical axis and bowling balls on the horizontal axis, we would see a linear "curve" to production. The slope would be calculated as 100/400 = 0.25, meaning that we lose 1/4 bicycle for each new bowling

Why I think Immigration Should Be Allowed Consider the following thought experiment: Moved by the plight of desperate earthquake victims, you volunteer to work as a relief worker in Haiti. After two weeks, you’re ready to go home. Unfortunately, when you arrive at the airport, custom officials tell you that you’re forbidden to enter the United States. You go to the American consulate to demand an explanation. But the official response is simple, “The United States does not have to explain itself

Introduction Manufacturing of cars is one of the most powerful businesses today wherein there is a wide range of companies and organizations that are involved. It is one of the world’s most important economic sectors by revenue because consumers are really into it, they are willing to produce a huge amount of money to have those innovative automobile products, definitely cars have advantages and disadvantages not only to the users, but as well as to society and the economy, however the continuous

to the оverstimulatiоn. Agonists of those receptors increase the cAMP levels, inverse agonists reduce those levels. However, it has been shown in vivo that inverse agonists such as metoprolol and bispolol cause improvement in mortality rates in mice models, xamoterol – an agonist used increased the mortality, while carvedolol – a neutral antagonist, did not have any effect (Greasley and Clapham, 2006). Other types of drugs that target GPCRs have agonist activities. Agonists are described as compounds

for FVC readings are between 80% and 100%. Mike has a reading of 65% which would be considered abnormal. Mike’s bronchoconstriction is causing reduced airflow, so he is unable to produce enough air. 7. Albuterol is a selective beta-2 adrenergic agonist, which means it specifically activates beta-2 adrenergic receptors on smooth muscle in the airways. How does this improve Mike’s asthma? - Albuterol is used to relax the muscles that are in the bronchioles to relieve breathing. It relaxes smooth

Discovery, structure, class and associated physiochemical properties Haloperidol is an antipsychotic drug used in the treatment of schizophrenia. It was discovered by Bert Hermans in 1958 at Janssen Laboratories in Belgium. Haloperidol is placed in the class of butyrophenones. The chemical formula for haloperidol is C21H23ClFNO2. The IUPAC nomenclature for haloperidol is 4-[4-(4-chlorophenyl)-4-hydroxypiperidin-1-yl]-1-(4-fluorophenyl)butan-1-one. Figure 1: 2-D structure of haloperidol (taken from