1. Introduction Liver disease represents a considerable public health burden that involves several etiologies overlapping symptoms (El-Serag & Rudolph, 2007). Since the seventies, the experimental model of carbon tetrachloride (CCl4) hepatotoxicity have been closely studied using in vivo models of acute and chronic liver injury. This process has been used comprehensively to examine the pathogenesis of liver injury such as centrilobular steatosis, inflammation, apoptosis and necrosis. CCl4 deteriorates
Introduction: Before the education of nurses took place in institutions of third level, nursing evolved into a practice that included teaching and demonstrating healthcare actions to patients, their families, other healthcare workers and the community at a large. (REF). Learning is the process of transforming experiences into knowledge, skills and attitudes, values and feelings. (REF). There are various learning theories that give insight into how a person learns. (REF). Teaching can be defined as
Opening: Liver function tests are blood tests used to diagnose and screen the function of the liver. The tests measure enzymes that liver cells release in response to damage or disease. Here is some more detailed information about these common tests. Body: Liver function tests can have the objective to: • Measure the severity of a disease, especially cirrhosis; • Monitor potential side effects of some drugs. • Screen for liver infections, such as hepatitis; • Monitor the development of a disease, such
to Cirrhosis Cirrhosis is a chronic liver disease that is characterized by normal liver cells being replaced by scar tissue. This affects the normal functioning of the liver and usually occurs from years of damage to the liver, resulting in inflammation, scarring and thickening of the fibrous tissues. It is most often a result of chronic hepatitis C or alcoholism, however there are other causes which will be discussed throughout this paper. Why is the liver important? More often than not, a person
diagnosed with Hepatic Cancer, known as Liver Cancer. Sadly, he died a few days after he was diagnosed. Many have dealt with not knowing what Hepatic Cancer can do to you, so I want to show you how serious this disease can be. The information you will gain knowledge of is what liver cancer is, how many types of forms are there, and how to prevent the deadly disease. What is the liver? Do you know? The liver is an important organ to our body. The liver produces bile and blood proteins, stores
dark reddish-brown color. With an adult liver weighing an average of three pounds, it is the largest glandular organ. The liver is located in the right hypochondriac region and is made up of two different lobes. There is the right larger lobe and the left smaller lobe. There are 1.5 quarts of blood transported to the liver every minute through the hepatic artery and portal vein. Because the fact that the liver produces bile it is considered a gland. The liver is part of the digestive system. This
An anti-epileptic drug (AED) currently under development caused 10% of the mice in the study to develop liver failure. The metabolism of the majority of AEDs is through hepatic biotransformation; Vigabatrin and Gabapentin are two exceptions. The afflicted mice in the new AED study were receiving the highest daily dose of the drug, which caused a metabolite to form in the liver of the mice, leading to the hepatotoxicity, indicating that this AED falls into the category of the majority of AEDs being
a high quantity. These types of disorders occur when an organ is diseased, but can also be the result of genetics, like Wilson’s disease. Wilson’s disease is an autosomal recessive disorder in which there is a copper build-up in the body, and can be fatal unless diagnosed and treated early. Treatment options include zinc therapy, chelator therapy and in some cases, liver transplant. The body uses copper as a key role in maintaining healthy development. Copper is beneficial
Autoimmune hepatitis is a rare chronic disease and it is lasts for many years. In this disorder liver get long-term inflammation because body’s own immune system attacks the liver. It is important to treat this disease because if not it can lead to cirrhosis and liver failure. 70% of patients with autoimmune hepatitis are women and they are usually between the ages of 15 and 40. It is most common in people that already have other autoimmune diseases. Type 1 diabetes, thyroiditis, ulcerative
The liver is responsible for hundreds of functions; it is the largest and most complex organ in the body. Weighing in at three pounds it sits behind the ribs on the upper right side of the abdomen and almost covers the entire width of the body. Nutrients and energy, the body 's fuel supply, is processed, converted and distributed by the liver. So, if anything obstructs these processes it will have a serious impact on the body as a whole. And the biggest obstacle would be the presence of gallstones
1.4 Radiation-induced inflammation Ionising radiation causes liver inflammation and injury, and a significant increase in the number of non-parenchymal liver cells has been reported following irradiation (Geraci and Mariano 1993). It is essential to explore the molecular mechanisms underlying the leukocyte transmigration processes to gain an understanding of the inflammatory disorders associated with RILD. Alcoholic liver disease, viral hepatitis and nonalcoholic steatohepatitis are the most common
Acute Liver Failure One of a vital organ of the human body is the liver. The liver is a largest glandular organ in the body and has multiple critical roles. Liver maintains the body of toxins and harmful substances, also liver produces bile that helps to digest fats. Without a healthy liver, life is not possible. Once the liver is damaged, because a virus or harmful chemicals or for any other reason, it will lose its ability to function and it is called liver failure is a life-threatening condition
about 35,000 people die of complications of cirrhosis each year.” (Civan) The liver is an expansive, substantial organ that sits on the correct side of the abdominal cavity. With this in mind, the liver roughly weighs three pounds, is rosy darker in shading and feels rubbery to the touch. Ordinarily, the liver cannot be felt, since it 's ensured by the rib cage, but is the biggest minimized organ in the human body. The liver 's primary activity is to channel the blood originating from the stomach origin
Many people once thought that diseases were in no way beneficial. However the book, "Survival of the Sickest" by Dr. Sharon Moalem, tells us about how certain diseases had an important role in the survival of our ancestors. Even though diseases are deadly and harmful, they helped our ancestors survive throughout history. Out of the many diseases stated throughout the book, I chose hemochromatosis, diabetes, and favism. Hemochromatosis is a hereditary disease that affects how the body processes
protein (figure1-14). In the bloodstream, chylomicrons acquire apoC-II and apoE from plasma HDLs [120]. The major sites for removal of chylomicrons are the muscle and liver. where they are metabolized further [120] as shown in. figure(1-15) Figure (1-14 ) chylomicron structure
Definition of Liver Cirrhosis Cirrhosis is a complication of many liver diseases characterized by abnormal structure and function of the liver. The diseases that lead to cirrhosis do so because they injure and kill liver cells, after which the inflammation and repair that is associated with the dying liver cells causes scar tissue to form. The liver cells that do not die multiply in an attempt to replace the cells that have died. This results in clusters of newly-formed liver cells within the scar
Yellowing of the skin and whites of the eyes.May result from blockage of the channel draining bile from the liver into the intestines or excessive breakdown of red blood cells. Hemoglobin from destroyed RBCs is broken down, and in part, ends up in bile secretions Diverticulosis/diverticulitis – Small pouches may form along the walls of the large intestine called
HEPATITIS Hepatitis is a disease defined by the inflammation of the liver and characterized by the presence of inflammatory cells in the tissue of the organ. Hepatitis may occur with limited or no symptoms, but often leads to jaundice, poor appetite, and malaise. Hepatitis is acute when it lasts less than six months and chronic when it persists longer. Acute hepatitis can heal on its own, progress to chronic hepatitis, or even cause acute liver failure. Chronic hepatitis may have no symptoms, though
our bodies and the impossibility of infection. It is this mindset that has allowed Hepatitis B and other viruses to secure their survival and prevalence in the world. Hepatitis B is an inflammation of the liver caused by HBV, which is a double stranded DNA virus. The infection can lead to liver failure, cirrhosis, or hepatocellular carcinoma (Aspinall et al., 2011). HBV has been considered a “silent killer” because of its ability to hide undetected without causing symptoms to the infected persons
about one quarter of cholesterol will entering the lumen. Bile and sloughed cells of the intestinal epithelium come directly from most of cholesterol in lumen. In small intestine, some of them are dietary cholesterol, and among of them put there by liver via bile. Total cholesterol that passes through small intestine is only half is typically absorbed, and the rest is eliminated (faeces). In addition, the material is targeted for excretion through digestive tract is cholesterol in bile. There are