Why is Americas Destiny of Slaves and American Population changing? In the late 1800s , Mississippi, the nation’s largest cotton-producing state, was economically and politically dependent on cotton, as the entire South. It was indeed the South’s economic production. Mississippi’s social and economic histories in early statehood were driven by cotton and slave labor, the two then became involved in America. Cotton, was an intensive business, large numbers of workers required to grow and harvest cotton came from slave labor until the end of the Civil War. Therefore all crops were abanded and replaced by Cotton which caused damage on the soil. Cotton was dependent on slavery. Slavery was a large extent dependent on cotton. Although they worked,