Chapter 1 Tumors Are Vampires Research Paper

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1 Tumors Are Vampires
Angio (blood vessel) - genesis (origin): this word describes the process of the growth of new blood vessels. Blood vessels carry the oxygen and nutrients cells need to grow and proliferate. However, not every cell has the privilege of vessel-front living. Many have to wait for the nutrients to spread to them from the blood vessel, and so they receive less nutrients. So if a cancer cell is unlucky enough to be born in the tissue boonies, it’s tumor size is going to be limited. But cancer cells are ambitious and bloodthirsty. When a tumor reaches a certain size, it will release molecules which signals blood vessel cells to start dividing towards the cancer cells, in order to save them from oxygen deprivation and providing …show more content…

However, metastasis is a difficult process, as it requires detaching from a tumor, traveling through the blood vessel wall into the bloodstream, then traveling back out into a new organ to infect. Again, the TAMs mentioned above help the cancer accomplish this. Cells are stuck together by proteins, which need to be dissolved to release the cell. TAMs release enzymes that chew these proteins up, releasing the cancer cell, which can then travel into the bloodstream. Even worse, TAMs help establish a more hospitable environment in the organs that the cancer cell is most likely to colonize. They release molecules into the bloodstream that make the macrophages in the vulnerable organs produce their own molecules that attract the rogue cancer cell and other macrophages, creating a very cozy environment for the future tumor to grow, served by its adoring brainwashed macrophage fans.

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“TAMs can promote initiation and metastasis of tumor cells...Specifically, TNF-α, VEGF, and transforming growing factor-β (TGF-β), which are derived from TAMs in cancer tissues, are believed to be transported through the bloodstream to destination organs, where they induce macrophages to produce S100A8 and serum amyloid A3. Both S100A8 and serum amyloid A3 can recruit macrophages and tumor cells to these organs and promote the formation of metastatic foci “

4 Cancer cells convert their

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