Clomiphene citrate, more commonly known by its brand names Clomid and Serophene, is a drug prescribed to stimulate ovulation in order to treat infertility. This drug was created by Frank Palopoli in 1956 while he worked for Merrell Company. It was first successfully induced ovulation in women in 1961 and was approved by the Food and Drug Administration (FDA) in 1967(102)
It was approved for marketing in 1967 under the brand name Clomid. It was first used to treat cases of oligomenorrhea but was expanded to include treatment of anovulation when women undergoing treatment had higher than expected rates of pregnancy.(23)
Clomiphene was initially discovered to be effective in the treatment of polycystic ovarian (PCO) disease and other forms of
…show more content…
Clomiphene citrate is revolutionary drug for infertility as it is easily available and cheaper amongst the other drugs for infertility. In easy terms Clomid is a first-line fertility treatment that blocks estrogen receptors and tricks a woman’s body into thinking it is low in estrogen. This trick stimulates the production of follicle stimulating hormone (FSH) and luteinizing hormone (LH), both of which are needed to induce …show more content…
As currently prescribed, CC is a racemic mixture of two distinct stereoisomers, enclomiphene and zuclomiphene, having different properties. Available evidence indicates that enclomiphene is the more potent isomer and the one primarily responsible for the ovulation-inducing actions of CC. Levels of enclomiphene rise rapidly after administration and fall to undetectable concentrations soon thereafter. Zuclomiphene is cleared far more slowly; levels of this less active isomer remain detectable in the circulation for more than 1 month after treatment and may actually accumulate over consecutive cycles of