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Clopidogrel Research Paper

191 Words1 Pages
Clopidogrel (plavix) is an antiplatelet therapeutic agent belongs to the thienopyridines drug class of which necessitate metabolic conversion into the active drug by the cytochrome P450 (CYP) family of liver enzymes, primarily by CYP2C19 that inhibits the purinergic P2RY12 receptor selectively and irreversibly , and thus platelet aggregation. It is used to prevent heart attacks and strokes whereas it is considered as a treatment for Acute Syndrome of the Heart, Unpredictable Severe Constricting Chest Pain, Myocardial Reinfarction, Acute ST Elevation Myocardial Infarction,Peripheral Artery Thromboembolis. The drug is largely ( 85%) hydrolyzed to inactive forms by esterases whilst only about (15%) is tranformed to the active form by hepatic
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