ipl-logo

Docetaxel Research Paper

1000 Words4 Pages

DOCETAXEL
Docetaxel is an anti-mitotic chemotherapy medication that is used to treat breast, ovarian, lung cancer, docetaxel is given intravenously, docetaxel was first approved by the FDA IN 1996, 11 years ago docetaxel was approved again by the FDA on October 17th 2006, docetaxel binds to microtubules reversibly with high affinity. Docetaxel is well known under a brand name Taxotere, Docetaxel belong to a chemical called taxoid. Docetaxel promotes the formation of microtubules that do not function properly. Microtubules aid the replication of cells by disrupting this function and docetaxel inhibits cell replication. There is an active ingredient of 20mg and 80mg of taxotere.
Nowadays, most people do not experience any side effect, the side effects depend on how much dosage, these are side effects that has occurred on cancer patients over the year, side effects such as low white blood cell count, this can cause the increase of the risk of patient getting infection, docetaxel also cause low red blood cell count which is Anaemia, nausea, diarrhoea, hair loss, fatigue, infection, nail changes in colour (finger nails and toe nails).
Docetaxel is not to be taken when pregnant or breast feeding.

Structure of docetaxel

Docetaxel has a hydroxyl functional group on carbon 10, the carbon 10 functional group …show more content…

Another mechanism of action is the altering of expression and phosphorylation of member of the bcl-2 family of proteins, docetaxel associate with the phosphorylation and inactivation of bcl-2 protein, members of the bcl-2 family are highly conserved proteins which regulate apoptosis. Docetaxel can display a wide spectrum of anti-cancer activity in preclinical trials. The clinical trial has shown that docetaxel is effective against hormone refractory prostate

Show More
Related
202 Words | 1 Pages

C4564 Description: IC50: 3-AP is a ribonucleotide reductase inhibitor and iron chelator with antitumor activity. Ribonucleotide reductase, the rate-limiting enzyme for de novo DNA synthesis, is an excellent target for chemotherapy. Its increased activity in cancer cells is associated with malignant transformation and proliferation.

Read More
572 Words | 3 Pages

Clinical Question: Should divalproex or gabapentin be used for female adolescents with partial focal seizures and decreased liver function? Evidence Based Answer: Gabapentin and divalproex are both effective anticonvulsant medications for partial seizures in female adolescent patients1,2. However, divalproex has adverse effects that are detrimental to patients with preexisting liver impairment3. Gabapentin does not have these detrimental effects on the liver like divalproex does because it is eliminated from the body through the kidneys instead of the liver4. If divalproex is more effective for the patient than gabapentin it may be paired with diammonium glycyrrhizinate to combat the detrimental effects on the liver.

Read More
1227 Words | 5 Pages

Main side effects Respiratory depression, light headedness, sedation, dizziness, nausea and vomiting, constipation, abdominal pain. Patient education To take Morphine with meals to avoid abdominal cramps and nausea. To avoid driving and carry heavy machines.

Read More
183 Words | 1 Pages

Wheaton says his medication makes him heat-sensitive, have cotton mouth, head buzzes, and even dizziness. Even with these terrible side effects, he knows it is better than going without taking

Read More
1011 Words | 5 Pages

Percocet Withdrawal Treatment Percocet is a combination of acetaminophen and oxycodone. Acetaminophen is a pain reliever which is less potent but its effect increased when it is combined with oxycodone. Oxycodone is an opioid pain medication. Percocet is often used as a prescription drug to relieve moderate to severe pain. But too much of Percocet dependency leads to addiction of it.

Read More
573 Words | 3 Pages

10 Things To Consider While Using Clenbuterol Looking for bodybuilding and have a thought of using Clenbuterol for it? Yes, Clenbuterol is a powerful supplement to use as itself but most of the people prefer using it in a stack which can enhance the overall results. Using Clenbuterol in a stack of several supplements can help you in faster muscle mass increase and also help to cut the weight easily. You can combine it with steroids or supplements such as dieta con clembuterol to achieve the desired result.

Read More
654 Words | 3 Pages

Also enjoyed by more than just practicing Santeros is the musical influences of Santeria. Since an entire generation of Cuban artists fled or were exiled from the island when the Communist Fidel Castro came into power, the development of Cuban music suffered greatly. As a result of this missing domestic creativity, modern Cuban music is a fusion of different genres from abroad. With each imported genre, Cubans have added their own spin to the music. Though pure Cuban music is now rare, one surviving element of the native music is the upbeat rhythm produced by the usage of 3 different hand drums called tambors.

Read More
1823 Words | 8 Pages

Prescription drugs pose many health risks including both short term and long term side effects. Every prescription information sheet from any local pharmacy lists a plethora of warnings, cautions, and possible side effects. In many cases, the patient is forced to wonder if the prescription drug will help their illness, or cause further medical issues. Side effects that are considered “mild” are still troubling. Side effects such as drowsiness, sleeplessness, muscle pain, dizziness, nausea and bouts of depression may not appear to be harmful but can cause serious consequences.

Read More
124 Words | 1 Pages

Maddix is an eight year old boy, in the second grade at Imagine Charter School. He is a very sociable and intelligent child. Maddix expressed a love for animals and states he has two dogs, two geckos, and ten fish. His favorite animal is a gecko But portraits and animals are what he draws most of the time. Maddix has a sketch book that he created in his art class.

Read More
603 Words | 3 Pages

There are quite a few serious side effects associated with taking Symbicort that you should be aware of. Pneumonia and other lower respiratory tract infections are possible side effects. However, people with COPD have a higher chance of getting pneumonia. 1COPD, or chronic obstructive pulmonary disease, is a chronic inflammatory lung disease that causes obstructed airflow from the lungs. Symptoms include a change in the amount or color of mucus, fever, experiencing chills, and increased coughing or breathing problems.

Read More
1495 Words | 6 Pages

WBRT is an effective and treatment of choice in patients with both identifiable brain metastases and prophylaxis for microscopic disease. WBRT has been reported to improve symptoms of brain metastases in 64-83%of patients, although some of the improvement is also a result of corticosteroids. [8,9,10] Even with this symptom improvement, recurrence is common, and control of brain metastases may only be achieved in half of the patients. Patients with tumors that are more radiosensitive to the effects of radiation such as lung and breast cancer cells have a better outcome than those with radioresistant tumors such as melanoma and renal cancers. Many patients receive WBRT in combination with another therapy such as surgery, radiosurgery, and chemotherapy.

Read More
1151 Words | 5 Pages

Headache, drugged feeling, confusion, anterograde amnesia, excessive sedation, lightheadedness, delirium, nightmares, hallucinations, nervousness, and agitation have also been reported. Chronic use in high doses and subsequent withdrawal may induce grand mal seizures. Cases of falls have been reported in elderly patients. Musculoskeletal side effects including arthralgia and myalgia have been reported, immunologic side effects including infection have been reported, hepatic side effects include one case of hepatotoxicity, Genitourinary side effects including urinary incontinence and urinary tract infection, cardiovascular side effects including palpitations, and respiratory side effects have included respiratory depression which may occur at high doses, may also cause upper or lower respiratory tract infection and rhinitis. Ambien has raised concerns about people doing things in their sleep such as walking, eating, driving, etc.

Read More
147 Words | 1 Pages

Hi, this is Maggie Ganley. I hope everything's going well this year and none of your students are driving you too crazy. I can say that this school year has definitely been a whole new experience for me. The adjustment to college has been an interesting one but it's getting easier as time goes on, even if my calculus still class drives me crazy from time to time (the adjustment from high school Algebra II to college Calculus is a bit of a stretch).

Read More
261 Words | 2 Pages

Dwerp’z essay on The Axolotl Hello, this is my crappy essay on the Axolotl, aka the Mexican Salamander/Mexican Walking Fish. In 1325, the Aztecs founded the city of Tenochtitlan, on a small island in Lake Tex-coco, where axolotls mainly lived. Later, the Spanish raided {I think.} and drained the lake and killed hundreds of axolotls {so sad} and built the city of Mexico aka Mexico City.

Read More
1466 Words | 6 Pages

Currently there are three medications, Teriflunomide, Fingolimod and Dimethyl Fumarate. While these medications offer the convenience of a pill they have considerable and potentially dangerous side effects. Teriflunomide (Aubagio) works by blocking the enzyme dihydroorotate dehydrogenase, which inhibit rapidly dividing cells like those of the immune system. Serious side effects include inability to fight infection, breathing problems and high blood pressure. Other side effects include: headache; diarrhea; nausea; hair thinning or loss; and abnormal liver test results.

Read More

More about Docetaxel Research Paper

Related Topics

Open Document