ipl-logo

Cyclosporine: The Immune System

1408 Words6 Pages

Cyclosporine
Transplantation is the act of transferring cells, tissues, or organs from one site to another. The malfunction of an organ system can be corrected with transplantation of an organ (eg, kidney, liver, heart, lung, or pancreas) from a donor. However, the immune system remains the most formidable barrier to transplantation as a routine medical treatment. As the immune system is responsible for the rejection of grafts understanding the mechanisms by which the immune system reject the graft helps in the treatment and development of drugs and ways that insure the success of the transplantation.
Types of Grafts:
The degree of immune response to a graft depends partly on the degree of genetic disparity between the grafted organ and …show more content…

Class I molecules, these are normally expressed on all nucleated cells, whereas the class II molecules are expressed only on the professional antigen-presenting cells (APCs), such as dendritic cells, activated macrophages, and B cells. The physiological function of the MHC molecules is to present antigenic peptides to T cells, since the T lymphocytes only recognize antigen when presented in a complex with an MHC molecule. The class I molecules are responsible for presenting antigenic peptides from within the cell (eg, antigens from the intracellular viruses, tumor antigens, self-antigens) to CD8 T cells. The class II molecules present extracellular antigens such as extracellular bacteria to CD4 T …show more content…

Hypertension occurs in ∼50% of renal transplant and almost all cardiac transplant patients. Hyperuricemia may lead to worsening of gout, increased P-glycoprotein activity, and hypercholesterolemia. Nephrotoxicity occurs in the majority of patients and is the major reason for cessation or modification of therapy. Combined use of calcineurin inhibitors and glucocorticoids is particularly diabetogenic. Especially at risk are obese patients, African-American or Hispanic transplant recipients, or those with a family history of type II diabetes or

Show More
Related

Nt1310 Unit 1 Case Study Answers

424 Words | 2 Pages

An Autograft is a graft taken from one part of the patients own body and placed on the part of the body needing a graft. There is no risk of rejection with an Autograft because the cells are your own and not seen as a foreign object. An Allograft is a graft from a cadaver a donor from the same species that is harvested in a tissue bank. When using this graft the patients immune system must be suppressed to further prevent rejection of the transplant. Allograft.

Read More

Organ Donations In The Book 'The House Of The Scorpion'

257 Words | 2 Pages

My opinion is that organ transplant should not be allow for many reason. Many people are marketing illegal kidney. So how they getting them? The reasons are in the book “The House of The Scorpion” because El Patron was a drug lord who made an empire full of slaves, clones, and people.

Read More

Arizona Health Care System Case Study

2276 Words | 10 Pages

(Varley 1988, 318-319). Dr. Schaller’s ethical concerns eventually led to his attempts to deny transplant requests.

Read More

Give Up A Kidney To Keep Her 29-Year-Old Cousin Alive?

698 Words | 3 Pages

The successful transplant surgery was performed two months later in March of 2000.... The ability to keep someone alive by replacing one or more of their major organs is an astounding achievement of 20th-century medicine. Unfortunately, the current supply of transplant organs is much lower than the need or demand for them, which means that thousands of people die every year in the U.S. alone for lack of a replacement organ. Ethical issues arise in connection with both the Procurement of transplant organs as well as

Read More

Consensus Statement On Live Organ Donor

1158 Words | 5 Pages

This application actually brings some benefits to our lives. Since money becomes an incentive, the huge gap between supply and demand of human organs can be filled. As a result, thousands of people’s lives will be saved. Since 2004, it is estimated that every 14 minutes passing by, there is an average addition of 106 people into the transplant recipient list. While the number of patients needed transplant surgery increases every day, the quantity of donors tends to be stable.

Read More

Persuasive Essay On Xenotransplantation

1122 Words | 5 Pages

Zoe Imagine being on a national organ transplant list and have been given a choice. Do you want a human organ or an animal organ? Yes, Xenotransplantation is a large medical breakthrough, but it come with a tremendous amount of risk involved. Animal organs are not meant to be in a humans body. Therefore, human organs should be used for people on the donation list instead of Xenotransplantation.

Read More

Xenotransplantation And Ethical Dilemmas

818 Words | 4 Pages

Doctors would then have to inject the body with immunosuppressive drugs, and the recipients would most likely have to take these drugs for the rest of their life, costing them hundreds of dollars (Joo, Kim, Kang, and Lee, 2010). In the end, my opinion on the subject has changed since I first began my research. I am now against the testing and research of Xenotransplantation, and would rather have scientists and doctors focus on ways on how to use human cells as a solution to the organ shortage, as I had mentioned in my personal

Read More

Organ Donation Ethics

1117 Words | 5 Pages

When dealing with this issue, it should not be forgotten that this is a discussion of life and death, where a decision is made on who lives, who dies and why. This issue is also regarding real people who are suffering, and decisions made based on good ethics and proper understanding of social and religious aspects will facilitate and make the process less painful. Both the community and physicians should therefore approach organ transplant positively and objectively and treat ethical, social and religious issues as negotiable perspectives and not barriers to organ

Read More

Persuasive Speech

1829 Words | 8 Pages

According to a publication by the WebMD website, the number of people who need a transplant is way higher than the number of people who are willing to donate their organs ("Organ Donation Facts" ). Many people die waiting for an organ transplant.

Read More

The Pros And Cons Of Organ Transplantation

600 Words | 3 Pages

Unfortunately, these agents also have the potential to cause disease and to increase the risk of infections and malignancies. These immunosuppressive drugs may lead to unwanted side effects that if used continuously can cause deleterious effects to the patient, However, without these drugs, organ transplant rejection can ensue in the patient which could lead to death. Indeed, these situations are like double edge swords that involves different ethical issues that many physicians need to face and to think about deeply. With the increasing number of transplant patients, what we need are new sets of drugs that would prevent the occurrence of transplant rejection with less side

Read More

Pros And Cons Of Organ Transplants

1013 Words | 5 Pages

When organs in your body are injured or have failed usually an organ transplant is required. Organ transplants are considered to be the best treatment option every year. To start an organ transplant you will first need a donor. It is very rare that an organ donor is living, usually the

Read More

Argumentative Essay: The Controversy Of Organ Donation

1217 Words | 5 Pages

Organ donation is currently the only successful way of saving the lives of patients with organ failure and other diseases that require a new organ altogether. According to the U.S Department of Health and Human Services there is currently 122,566 patients both actively and passively on the transplant list. This number will continue to increase, in fact, every ten minutes another person is added to the list. Unfortunately, twenty-two of these people die while waiting for an organ on a daily basis. Each day, about eighty Americans receive a lifesaving organ transplant.

Read More

Pros And Cons Of Organ Transplants

633 Words | 3 Pages

“Each day, an average of 79 people receive organ transplants. However, an average of 21 people die each day waiting for transplants that can 't take place because of the shortage of donated organs” (The Need Is Real). There are many different views of the pros and cons that make up transplants of all kinds, from organ to bone transplants, and whether or not they should be allowed to be continued. There are a few cons of the different types of transplants. One of these negatives is that the donor usually does not get to choose who will receive his organs.

Read More

Argumentative Essay: The Ethics Of Organ Donation

733 Words | 3 Pages

There are nearly 100,000 people waiting patiently on organ transplant waiting lists, but sadly, on an average day, less than 80 people receive donor organs and approximately 19 die waiting for transplants. Even with

Read More

Disadvantages Of Organ Transplants

1648 Words | 7 Pages

Introduction The trade of human organs in order to transplant is illegal in most countries. The increasing demand for organs and increasing rate of trade show the importance of this issue in today’s world. According to WHO, 91 countries conduct organ transplantation and every 10th organ transplanted are illegal (World Health Organization 2010). Kidney and Urology foundation of America found that in the US in early 2010 there were more than 121,678 individuals waiting for a new organ and for about 34000 individuals are added every year (Kidney & Urology Foundation of America 2016).

Read More

More about Cyclosporine: The Immune System

Related Topics

Open Document