Early Jamestown Colonialism

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So many colonialists died in early Jamestown due to various reasons and factors. These include: Ecological difficulties, Settler Abilities and Their associations with the Indians.
In Jamestown they expected to get golden treasures and believed they were to discover a concealed or secret route to china. Some Indian families lived by the James River of which the colonists came through. This made it hard for the colonialists to interact and relate with them. This caused so many people to die.
In early Jamestown the people in question (colonialists) died due to depraved land/terrestrial quality. So many of them died from the brackish water as well as contaminated water. Human waste was the main source of water contamination. It as well stayed in