Fluorine Chemistry Lab Report

The condensation product between the aromatic aldehydes and the aromatic ketones are 1,3-diphenylprop-2-en-1-ones, which are commonly known as chalcones. If any other types of aldehydes and ketones are used, the product is frequently known as α,β-unsaturated ketones. Chalcones and α,β-unsaturated ketones have been captivating, the medicinal,[1] synthetic,[2] and applied chemists[3] by virtue of their structural units (Figure 1) which have been gained many access to tailor the molecule suitably for wide range of applications in medicinal,[1] synthetic,[2] and applied chemistry.[3] The fluorine has the special topic of interest among the chemists as its introduction into the organic molecules leads to a dramatic changes in their physical and chemical properties.[4] The recent activities show a remarkable growth in fluorine chemistry as the chemists practiced to do polishing the organic molecules with fluorine to improve their properties, leading to widespread applications in medicinal,[4b,c,5] agrochemicals,[6]

But, only handful of examples were available for the Pd-mediated [18F] labeling of organic molecules in which [18F] labeled aryl halides were the actual coupling partner to variety of nucleophiles.[8b] Moreover, the only Pd-catalyzed direct [18F]F-fluorination of aryl triflates was reported by J. Cardinale et al.[11] To date, no Pd-catalyzed C‒O cross-coupling methodology has been developed for [18F] fluoroalkoxylation of aryl halides in the [18F] radiotracer synthesis. The reason might be just attributed to, the chemists considering the relatively weak nucleophilic nature of simple alkyl alcohols (oxygen nucleophiles) which further ease off if it contains fluorine atom(s), and then this would not participate well with a greater rate in Pd-catalyzed C‒O coupling