Literature Review on The Unique Challenges in Clinical Trials of Iron Deficiency Anemia
Iron deficiency anemia is a medical ailment which mechanism is due to a lack of iron required for hemoglobin production. Anemia occurs when there is not enough hemoglobin and/or few red blood cells being produced in the body (Johnson-Wimbley, & Graham, 2011). Iron deficiency anemia is a disease that is caused by other diseases such as menorrhagia, gastrointestinal bleeding, peptic ulcer disease, and colorectal cancer. The prevalence of iron deficiency anemia is the highest in women of childbearing years and children (Johnson-Wimbley, & Graham, 2011). The demographics and patient population across the country are very vast and diverse, however the socio-economic class within these areas impact the prevalence of anemia. Men and women have different daily iron requirements for the maintenance of normal levels of hemoglobin, cytochromes and iron-sulfur complexes needed for
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The classification is based on the size of the red blood cell. Iron deficiency anemia is the most common cause of microcytic anemia. There are many different causes of this type of anemia such as gastrointestinal bleeding, bleeding from menstrual cycle in women, peptic ulcer disease in older men, and colon cancer in elderly people (Johnson-Wimbley, & Graham, 2011). By understanding the idea and mechanism of what this anemia is about will give a better understanding into how to diagnose this disease. There are certain type of people who obtain this disease such as women being the most common and children. The reason for that is on a monthly basis, women go through their menstrual cycle which begins with menses. Women shed blood from their uterus for a period of three to seven days. Because of that, they are losing iron which makes them more common than