Malaria is the most common disease in third world countries with a tropical climate; the disease is caused by a parasite called Plasmodium, which is transmitted through the bites of infected mosquitoes. In the human body, the parasites multiply in the liver, and then infect red blood cells. Symptoms of malaria include fever, headache, and vomiting, and usually appear between 10 and 15 days after the mosquito bite. If not treated, malaria can quickly become life-threatening by disrupting the blood supply to vital organs. In many parts of the world, the parasites have developed resistance to a number of malaria medicines.
Transmission occurs in large areas of Africa, central and South America, the Caribbean, Asia, Eastern Europe and the South Pacific.
The body’s natural defence mechanisms that fight malarial parasites are more common in populations of people, that are continually exposed to the parasite. Also for individuals with inherited conditions such as sickle cell anaemia and Thalassaemia, which are in fact conditions in which cause abnormalities in the red blood cells. It is also found within people that come from regions impacted by malaria. Therefore, because of the abnormalities that these conditions cause, it makes it
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Also the advancement of analogs of existing agents, the new findings of natural products, which may help in treating the disease and the use of drugs that were created to fight against other drugs. The evaluation of drug resistance reversers and the use of new chemotherapeutic targets. The last category benefits from recent advances in malaria research technologies and genomics and is most likely to identify new classes of drugs. Some new antimalarial therapies will probably be needed in the future, so it important to find different strategies of drug