Matthias Grünewald was a necessary part of the Renaissance, as he helped to spread many ideas about art and culture such as Systems of Faith, Humanism, and Mannerism to the Northern half of Europe. He mostly painted religious and Biblical scenes, but incorporated certain elements of the Northern Renaissance into his work. He uses lots of symbolism in his artwork and challenged the standards of artwork in his time. Matthias Grunewald was a pivotal piece of the Northern Renaissance as he helped to spread the cultural changes of the Renaissance to Northern Europe. Because of this, he is considered “one of the greatest German painters of his age.” Along with spreading culture, he also created artwork that challenged that of the Renaissance, therefore furthering the cultural development of the fifteenth and sixteenth centuries. Grunewald poured out his emotions into his artwork and inspired others to do the same, creating more dramatic and intense paintings and other pieces of art. Matthias Grünewald’s style of painting relied greatly on Systems of Faith and his Christian beliefs. The Isenheim altarpiece was painted by Matthias Grunewald around 1515 for the Monastery of St. Anthony near Colmar, France. This magnificent painting ties directly to the Bible. The pronounced details represent the mistreatment of Jesus and also relates to the monastery as a place where the sick and diseased are helped and taken care of. Its panels depict The Crucifixion of Jesus Christ, the martyrdom