RESULTS AND DISCUSSION Preformulation Studies The melting point of Metoprolol Tartrate was determined by capillary method and was found to be 121ºC (120 - 124ºC) as reported in literature, thus indicating purity of Metoprolol Tartrate. FTIR analysis showed that all the characteristic peaks of Metoprolol Tartrate and mixture of Metoprolol Tartrate with excipients were present in the range of reported frequencies; which shows that drug and excipients were compatible with each other. DSC thermogram of Metoprolol Tartrate alone showed endothermic peak at 120.73°C, corresponding to the melting point of the drug. The thermal curve of the Metoprolol Tartrate obtained indicated its crystalline anhydrous state, exhibiting a sharp endothermic peak at 120.73°C. The …show more content…
s q. s q. s q. s q. s q. s Table no.1 Formulation Table Table No.2: Physicochemical properties of the prepared buccal patches of Metoprolol Tartrate Formulations Folding Endurance* Tensile Strength* (%) Percentage Elongation* (%) Percentage Moisture absorption* (%) Percentage Moisture loss*(%) Drug Content* (%) F1 315 ± 2.516 38.72±1.10 143±1 3.89±0.67 1.5±0.82 91.64±1 F2 326 ± 2.081 46.71±1.505 122±1 4.19±0.75 1.4±0.97 94.60±1.174 F3 328 ± 2.645 42.43±0.735 121±1 5.11±0.94 2.1±0.65 93.25±0.960 F4 318 ± 1.527 49.34±1.01 142±1 3.75±0.81 1.3±0.23 97.80±0.990 F5 345 ± 2.081 46.93±2.16 125±1 4.69±1.32 2±0.71 90.60±0.995 F6 358 ± 2.081 51.31±1.00 134±1 3.45±0.84 1.5±0.84 89.03±1.000 *Data expressed as mean ± SD