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Nucleotide Excision Repair Lab Report

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Nucleotide excision repair is an important DNA repair system that corrects UV induced genetic damages. One example of such damage is the formation of a covalent bond between two adjacent thymine bases on a DNA strand (thymine dimers). This causes a bulk in the DNA strand and disrupts DNA replication.
The process includes the proteins UvrA, UvrB and UvrD as well as DNA polymerase and DNA ligase. First, a protein trimer, which is composed of two UvrA molecules and one UvraB molecule, scans the double helix for any distortions. Once a thymine dimer is detected, the trimer stops. The two UvrA proteins are released leaving behind UvrB. UvrC attaches to the damaged site and makes two incision on either side of it. A helicase known as UvrD then binds
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