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Personal Statement Of Purpose: What Makes A Cyst Cancerous?

1336 Words6 Pages

Science helps us in finding reasons behind the Biological processes and the technology aids the development of the novel strategies to manipulate it. Before joining the graduate school, I wanted to gather knowledge of both scientific and technical research. According to me, research is a beautiful piece of a sketch made by joining the dots of the knowledge gathered from the academics. I believe, that a graduate program will give me that opportunity to join the dots which I have gathered by studying Biochemistry and Biochemical Engineering to create an amazing sketch of life.
I am leading to the ultimate goal of my life by taking small steps every day. I am looking for that day when I will be successful in applying my knowledge for the betterment …show more content…

The doctors predicted the cyst to be malignant. It was the period when I was learning about cancer and apoptosis of cells. A very broad question which came to my mind was “Why Cancer?”. After 15 days of operation, the histopathology report suggested that the cyst was benign. Then the question which came to my mind was “What makes a cyst cancerous?”. This situation made me study the literature of diagnostic and therapeutic research on cancer. Today after five years of that incidence I reached to a specific molecular level question “How to inhibit the ERK2 in Raf-MEK-ERK pathway to suppress the growth of cancerous cells? ”. I believe, pursuing a graduate program will help me in designing more challenging questions and also will provide a requisite platform to address those …show more content…

In my own quest to a suitable graduate program that resonates my interest, I was thrilled to learn about the work of Prof. Lawrence A. Quilliam on the role of Rap1A in glioblastoma tumor growth by it's in vivo down-regulation. I have found this work aligned to my research interest in targeting the Raf-MEK-ERK pathway for tumor growth suppression. While going through the literature for elucidating the role of the metal binding site in staphylococcal exotoxins, I came across the work of Prof.Millie M. Georgiadis and I appreciate the novel finding of plasticity in the metal binding site of apurinic/apyrimidinic endonuclease-I. The exposure to the peptide mass fingerprinting of ERK2 has driven me through the possible outcomes of this method. The research planning of Prof. Aruna Wijerante about the application of mass spectrometry-based biochemical analysis and proteomics to study various diseases also attracted my

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