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Rat Model Of Activity-Based Anorexia

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Robin B. Kanarek, Kristen E. D’Anci, Nicole Jurdak, & Wendy Foulds Mathes. (2009). Running and addiction: Precipitated withdrawal in a rat model of activity-based anorexia. Behavioral Neuroscience. (123)(4), 905-912. doi: 10.1037/a0015896 Introduction In the study “Running and Addiction: Precipitated Withdrawal in a Rat Model of Activity-Based Anorexia” Robin B. Kanarek, Kristen E. D’Anci, Nicole Jurdak, and Wendy Foulds Mathes of Tufts University are researching the question of whether or not excessive exercise can create an addicted state, then when the exercise stops, one might go through withdrawals, similar to those of opiate drugs. The hypothesis of this article is that “exercise-induced increases in endogenous opioid peptides act in …show more content…

Half of the rats were placed in cages without exercise wheels, and the other half where placed in cages that had exercise wheels in them. Each rat had equal access to food and water for the first 7 days. After the first week, 18 of the rats had their food restricted to 1 hour per 24 hour period. Another group of 18 rats, 10 rats with access to the exercise wheel, 8 without, maintained free access to provisions. The last group of 8 rats with no exercise wheel was fed the average amount of food eaten the day before, by the rats with exercise wheels on the restricted diet. After some time, they injected the test subjects with a constant amount of naloxone HCL, then observed them for one hour by two separate perspectives, who did not know the conditions of the experiment, to look for signs of withdrawal. (Robin B. Kanarek, Running and Addiction). The results of the first experiment showed that the active female rats with limited access to food resources displayed the clearest symptoms of withdrawals. Next came the active female rats with unlimited access to food resources. After that, the inactive female rats with limited food resource access, and finally, the inactive female rats with unlimited access to food showed the least amount of withdrawal

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