Sanger's DNA Double Helix Model

At the dawn of 20th century the field of genetics witnessed something extraordinary, the rediscovery of Mendel, which paved our way towards understanding the pattern of inheritance. Although with this the foundation of modern ear genetics was laid scientists were still clueless about the chemical nature of genetic material. Later in the middle of 20th century crucial evidences supporting DNA as a genetic material came into picture and ultimately which lead towards the discovery of DNA double helix. This perhaps revolutionized the whole world of biological sciences. Watson and Crick DNA double helix model supported all the previous assumption which were related to what should be the features of anything to be called as genetic material. Although, by now it was confirmed that DNA is a genetic material and the structure was

H.G Khorana who proved that the genetic code in a three letter code which carries information for all the amino-acid which are present in the protein. Now as the bits and tits of whole story were assembled the science was progressing towards providing answer of another important question: how to decode the information present in the DNA and how it can be made accessible to the mankind for harnessing its true potential. This was simplified by discovery of a facile DNA sequencing technology popularly known as Sanger’s sequencing named after its inventor Fredrick Sanger. With little bits of refinements, for more than three decades was only the one which was used routinely for sequencing DNA. In fact all the first reports of genome sequencing were an outcome of Sanger’s sequencing. In the fag end of the first decade of 21st century some new high throughput genome sequencing technologies were discovered which would later on revolutionize the way genome were to be sequence. The whole arsenal of these technologies was termed as Next Generation Sequencing